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MetabolomicsMetabolomics analysis of the toxic effects of the production of lycopene and its precursors
Using cells as microbial factories enables highly specific production of chemicals with many advantages over chemical syntheses. A number of exciting new applications of this approach are in the area of precision metabolic engineering, which focuses on improving the specificity of target production....
2021-02-11 | MTBLS642 | MetaboLights
MetabolomicsDeep longitudinal multi-omics analysis of Bordetella pertussis cultivated in bioreactors highlights medium starvations and transitory metabolisms, associated to vaccine antigen biosynthesis variations and global virulence regulation

Bordetella pertussis is the bacterial causative agent of whooping cough, a serious respiratory illness. An extensive knowledge on its virulence regulation and metabolism is a key factor to ensure pertussis vaccine manufacturing process robustness. The aim of this study was to refine our ...

2023-02-21 | MTBLS5762 | MetaboLights
MetabolomicsProduction of new microbially conjugated bile acids by human gut microbiota

Gut microbes have been recognized to convert the human bile acids by deconjugation, dehydroxylation, dehydrogenation and epimerization of the cholesterol core, but the ability to re-conjugate them with amino acids as an additional conversion has only been recently described. These new bile acids ...

2024-01-16 | MTBLS4140 | MetaboLights
MetabolomicsComprehensive Analysis of Differences in Cashmere Production Performance in Liaoning Cashmere Goats by Using Metabolomics and Transcriptomics

This study integrated transcriptomics and metabolomics to analyse the molecular differences in the skin tissues of perennial long wool type (PT-LCG) and seasonal long wool type (ST-LCG) Liaoning cashmere goats to reveal the regulatory mechanisms underlying their differences in cashmere production...

2025-11-27 | MTBLS13406 | MetaboLights
MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
GenomicsBacillus anthracis strain:Antigen 34
Bacillus anthracis strain:Antigen 34 Genome sequencing
PRJNA1235450 | ENA
MetabolomicsInduction of resistance against Sclerotinia sclerotiorum in rapeseed by β-ocimene through enhanced production of coniferyl aldehyde

Rapeseed (Brassica napus) is an important oil resource, but its yield can be significantly compro-mised by Sclerotinia sclerotiorum (S. sclerotiorum) infection. Due to the lack of rapeseed strains that are highly or completely immune to S. sclerotiorum, enhancing rapeseed resistance through genet...

2025-07-04 | MTBLS12510 | MetaboLights
TranscriptomicsExpression Data from WT and Sh2d1a-/- in vivo follicular helper CD4 T cells (TFH) versus non follicular helper CD4 T cells (non-TFH)
CD4 T cell help is critical for both the generation and maintenance of germinal centers, and T follicular helper (TFH) cells are the CD4 T cell subset required for this process. SAP (SH2D1A) expression in CD4 T cells is essential for germinal center development. However, SAP-deficient mice have only...
ORGANISM(S): Mus musculus 
2010-04-28 | E-GEOD-21379 | biostudies-arrayexpress
TranscriptomicsToll-like receptor 2 (TLR2)-TLR9 crosstalk dictates IL-12 family cytokine production in microglia
Microglia are the resident mononuclear phagocytes of the CNS parenchyma and represent an initial line of defense against invading microorganisms. Microglia utilize Toll-like receptors (TLRs) for pathogen recognition and TLR2 specifically senses conserved motifs of gram-positive bacteria including li...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-24935 | biostudies-arrayexpress
ProteomicsMutations in epitope flanking regions for SARS-CoV-2 nucleoprotein affect proteasomal processing to alter CD8+ T cell responses
Viral CD8+ epitopes are generated by the cellular turnover of viral proteins, predominantly by the proteasome1. Mutations located within viral epitopes can result in escape from memory T cells2. Focussing on two of the most dominant SARS-CoV-2 nucleoprotein CD8+ epitopes3,4, we identified mutations ...
ORGANISM(S): recombinant SARS coronavirus 
2023-10-24 | PXD032054 | Pride
Lc-ms/ms Sars-cov-2 T-cell Antigen Epitope 
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