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MetabolomicsUntargeted Metabolomics To Ascertain Antibiotic Modes of Action
Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially rapid and cost-effective means of identifying modes of action of drugs whose effects are mediated through changes in metabolism. Metabolomics...
2017-06-16 | MTBLS464 | MetaboLights
MetabolomicsMetabolomic analysis of the mechanism of action of yerba mate extract on Salmonella Typhimurium
Background: Salmonella Typhimurium is a gram-negative enteropathogen that infects millions worldwide; the rapid emergence of antibiotic resistant strains has heightened the urgency of developing effective treatment for this pathogen. Previous studies have demonstrated that the aqueous extract of yer...
2017-02-16 | MTBLS359 | MetaboLights
MetabolomicsThe killing mechanism of teixobactin against methicillin-resistant Staphylococcus aureus (MRSA): An untargeted metabolomics study

The discovery of antibiotics has led to the effective treatment of bacterial infections that were otherwise fatal and has had a transformative effect on modern medicine. Teixobactin is an unusual depsipeptide natural product that was recently discovered from a previously unculturable soil bacteri...

2020-04-30 | MTBLS1569 | MetaboLights
TranscriptomicsE.coli response to Antimicrobial Arylamides
We treated logarithmically growing cultures of E.coli with a sub-lethal dose of an antimicrobial arylamide compound (PMX 10070) and Polymyxin B sulfate to measure transcriptional responses in an effort to understand mechanism of action Treated samples were assayed at time = 20min and time = 60min af...
ORGANISM(S): Escherichia coli 
2011-08-02 | E-GEOD-31140 | biostudies-arrayexpress
TranscriptomicsTraDIS-Xpress finds mechanisms of action and synergies of a novel lipid IVA biosynthesis inhibitor
We used TraDIS-Xpress to determine the mechanism of action of a novel antimicrobial compound. We found that it inhibits lipid IVA biosynthesis in both Escherichia coli and Salmonella enterica serovar Typhimurium. We also were able to determine mechanisms of synergy with colistin, through ATP biosynt...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2023-08-31 | E-MTAB-13250 | biostudies-arrayexpress
MetabolomicsHost-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However, further medicinal development is largely restric...
2018-02-12 | MTBLS452 | MetaboLights
ProteomicsFPOP AMP-Nanodisc Paper Reid et. Al. 2021
Raw and processed data from FPOP analysis of bovine indolicidin and human LL-37 antimicrobial peptides with nanodiscs composed of DMPC, DMPG, or E. coli polar lipid extract. Data is provided for both oxidized samples and control samples with no exposure to the UV laser.
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Escherichia Coli (ncbitaxon:562) Homo Sapiens (ncbitaxon:9606) 
MSV000088174 | MassIVE
GenomicsAntimicrobial action of t-cinnamaldehyde on Escherichia coli MG1655
Antimicrobial action of t-cinnamaldehyde on Escherichia coli MG1655
PRJNA1060668 | ENA
TranscriptomicsCampylobacter jejuni transcriptomic response to benzylisothiocyanate
Campylobacter jejuni is a widespread pathogen responsible for most of the food-borne gastrointestinal diseases in Europe. For pathogen control in the food industry, the use of natural antimicrobial molecules is a promising strategy to avoid antibiotic treatments. Isothiocyanates are natural antimicr...
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 
2013-09-19 | E-GEOD-45823 | biostudies-arrayexpress
ProteomicsThe examination of Pseudomonas aeruginosa proteome in the presence of phenolic acids
Pseudomonas aeruginosa, which is an important oppurtunistic pathogen, is a serious threat for human health, worldwide. New antimicrobial agents are in search and phenolic acids, secondary metabolites of plants, are promising candidates. In this project, the protein profile changes of Pseudomoas aeru...
ORGANISM(S): Escherichia coli 
2020-08-27 | PXD016243 | Pride
Phenolic acids Pseudomonas aeruginosa Antimicrobial action mechanism Lc-esi-ms/ms 
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