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MetabolomicsEffect of transplantation of irradiated mouse feces on blood short chain fatty acids in recipient mice
In order to study the effect of transplantation of irradiated mouse feces on the short chain fatty acids in the blood of recipient mice, we used mobile phones to transplant the feces of donor mice from 1W to 4W after irradiation. After 2W of antibiotic intervention, fecal bacteria were transplanted ...
2026-09-28 | MTBLS15752 | MetaboLights
MetabolomicsExogenous glutamate potentiates gentamicin to kill multidrug- and carbapenem-resistant Pseudomonas aeruginosa through activating biosynthesis of unsaturated fatty acids

Antibiotic-resistant Pseudomonas aeruginosa is a major clinical challenge due to limited drug uptake. This study shows that exogenous glutamate restores gentamicin efficacy by reprogramming bacterial metabolism to enhance membrane permeability. The effect is mediated through increased biosynthesi...

2025-09-22 | MTBLS12656 | MetaboLights
ProteomicsStaphylococcus aureus membrane vesicles confer resistance to antimicrobial fatty acids
S. aureus is a common commensal inhabitant of skin and nares of healthy individuals. In these environments, S. aureus overcomes colonisation barriers deployed by the innate immune system, which include long chain unsaturated free fatty acids with known potent anti-staphylococcal activity. S. aureus ...
ORGANISM(S): Staphylococcus aureus 
2021-09-09 | PXD018809 | Pride
Innate immunity Membrane vesicles Antimicrobial fatty acids 
TranscriptomicsS. aureus gene expression following growth in media containing oleic acid
S. aureus response to exogenous fatty acid (oleic acid) Gene expression profiles were generated by microarray analysis of S. aureus cells grown in media without or with oleic aicd Comparison of expression profiles after growth of S. aureus in exogenous fatty acid S. aureus was grown in media with an...
ORGANISM(S): Staphylococcus aureus subsp. aureus RN4220 
2012-12-21 | E-GEOD-36231 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Staphylococcus aureus in response to unsaturaed long chain free fatty acids
Data is also available from http://bugs.sgul.ac.uk/E-BUGS-68
ORGANISM(S): Staphylococcus aureus 
2009-02-04 | E-BUGS-68 | biostudies-arrayexpress
MetabolomicsBile acid is a significant host factor shaping the gut microbiome of diet induced obese mice (targeted free fatty acid analysis assay)

BACKGROUND: Intestinal bacteria are known to regulate the bile acid (BA) homeostasis via intestinal biotransformation of BAs and stimulating the expression of fibroblast growth factor 19 through intestinal nuclear farnesoid X receptor (FXR). On the other hand, BAs directly regula...

2017-11-23 | MTBLS548 | MetaboLights
ProteomicsThe type VII secretion system protects Staphylococcus aureus against host-specific fatty acids
The Staphylococcus aureus type VII secretion system (T7SS) exports several proteins that are pivotal for bacterial virulence. The mechanisms underlying T7SS-mediated staphylococcal survival during infection are nevertheless unclear. Here we show that EsxC, a small secreted effector implicated in bac...
ORGANISM(S): Staphylococcus aureus 
2021-09-08 | PXD013081 | Pride
Type vii secretion system Staphylococcus aureus Long-chain unsaturated free fatty acids 
MetabolomicsBile acid is a significant host factor shaping the gut microbiome of diet induced obese mice (targeted short chain fatty acid analysis assay)

BACKGROUND: Intestinal bacteria are known to regulate the bile acid (BA) homeostasis via intestinal biotransformation of BAs and stimulating the expression of fibroblast growth factor 19 through intestinal nuclear farnesoid X receptor (FXR). On the other hand, BAs directly regula...

2017-11-23 | MTBLS546 | MetaboLights
ProteomicsFASII antibiotic adaptation reprograms Staphylococcus aureus behavior
Proving functionality in the host environment is a crucial step in antimicrobial development pipelines. Antibiotics targeting fatty acid synthesis (FASII) of the major pathogen Staphylococcus aureus actively inhibit FASII but do not prevent in vivo growth, as bacteria compensate the FASII block by u...
ORGANISM(S): Staphylococcus aureus 
2023-10-09 | PXD034256 | Pride
Fasii antibiotic adaptation reprograms staphylococcus aureus behavior 
TranscriptomicsTranscription profiling of Arabidopsis to identify Tween 20 inducible genes
Polyethylene glycol sorbitan monoacylates (Tween) are detergents of widespread use in plant sciences. We show them, notably Tween 20, to cause a rapid and complex change in transcript abundance which bears all characteristics of a PAMP / elicitor-induced defense response, and they do so at concentra...
ORGANISM(S): Arabidopsis thaliana 
2009-11-10 | E-GEOD-5513 | biostudies-arrayexpress
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