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The proteome of Escherichia coli was established by shotgun proteomics and changes upon treatment with phosphinic compounds were measured, highlighting the potential of these new antimicrobials.
ORGANISM(S): Escherichia coli 
2024-11-06 | PXD051418 | Pride
Antimicrobials targeting cell wall biosynthesis are generally considered inactive against non-replicating bacteria. Paradoxically, we found that in non-permissive growth conditions exposure of Mycobacterium bovis BCG bacilli to such antimicrobials enhanced their survival. We identified a transcripti...
ORGANISM(S): Mycobacterium tuberculosis 
Extended period of selection for antimicrobial resistance due to persistency of antimicrobials in broilers
CRISPR-Cas systems can be utilized as programmable-spectrum antimicrobials to combat bacterial infections. However, how CRISPR nucleases perform as antimicrobials across target sites and strains remains poorly explored. Here, we address this knowledge gap by systematically interrogating the use of C...
ORGANISM(S): Klebsiella pneumoniae Escherichia coli 
2023-07-17 | GSE237136 | GEO
Coordinated protein-coding sequence transcriptional responses of Staphylococcus aureus to antimicrobial exposure are well described but little is known of the role of bacterial non-coding, small RNAs (sRNAs) in these responses. Here we used RNAseq to investigate the sRNA response of the epidemic mul...
ORGANISM(S): Staphylococcus aureus 
Pathogenic bacteria have acquired the ability to resist antibacterial defense mechanisms of the host. Streptococci are common in animal microbiota and include opportunistic pathogens like Group A Streptococcus (GAS) and Streptococcus pneumoniae (pneumococcus). While the conserved streptococcal S pro...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2026-06-08 | PXD055534 | Pride
Systematic interrogation of CRISPR-based antimicrobials in Klebsiella pneumoniae reveals nuclease-, guide-, and strain-specific factors influencing antimicrobial activity
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