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MetabolomicsAccumulation Characteristics of Flavonoids and Contribution to Antioxidant Capacity in Wild and Cultivated Kiwifruits

This study aimed to clarify flavonoids accumulation characteristics and their contribution to antioxidant capacity in wild type (WT) kiwifruit (Actinidia deliciosa) and three cultivated varieties (Xuxiang, XX; Yazui, YZ; Hongyang, HY). Integrating untargeted metabolomics and traditional biochemic...

2026-01-14 | MTBLS13683 | MetaboLights
MetabolomicsHow Does the Seed Pre-germinative Metabolism Fight against Imbibition Damage? Emerging Roles of Fatty Acid Cohort and Antioxidant Defence

During seed imbibition, lipids are engaged in membrane reorganization while facing free radical-mediated oxidative injury. In the present work, we explored changes in lipid components at different timepoints of imbibition (0.5, 2, 4, 6, and 8 h) in the legume Medicago truncatula, by combining bio...

2019-10-14 | MTBLS181 | MetaboLights
MetabolomicsRectal microbiomes and serum metabolomics reveal changes in serum antioxidant status and immune responses of Dezhou donkeys in late gestation to parturition

Background: Parturition is a critical event in the reproductive cycle of dairy animals, accompanied by multiple physiological changes in sex hormones, metabolism, antioxidant capacity and immune function. However, the changes in the rectal microbiota and metabolic products of Jennies from late ge...

2025-08-27 | MTBLS12897 | MetaboLights
MetabolomicsBiological Potential of Lophosoria quadripinnata Fern Extract: Integration of UHPLC/ESI/QToF/MS Analysis, Antioxidant Activity, Molecular Docking and Molecular Dynamics Simulation

Lophosoria quadripinnata (J.F.Gmel.) C.Chr., a fern species from the Dicksoniaceae family, is widely distributed in Central and South America. This study aimed to identify the bioactive compounds in the aqueous extract of L. quadripinnata, evaluate its antioxidant potential through in vitro analy...

2025-06-27 | MTBLS9336 | MetaboLights
TranscriptomicsTranscription profiling of human neuroblastoma cell line IMR-32 overexpressiong SQSTM1 and DPP3 to identify activators for the antioxidant response element
The antioxidant response element (ARE) is a cis-acting regulatory enhancer element found in the 5’ flanking region of many phase II detoxification enzymes. Upregulation of ARE-dependent target genes is known to have neuroprotective effects; yet, the mechanism of activation is largely unknown. By scr...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-6451 | biostudies-arrayexpress
MetabolomicsEnhancement of oxidative and drought tolerance in Arabidopsis by overaccumulation of antioxidant flavonoids
The notion that plants use specialized metabolism to protect against environmental stresses needs to be experimentally proven by addressing the question of whether stress tolerance by specialized metabolism is directly due to metabolites such as flavonoids. We report that flavonoids with radical sca...
2013-12-06 | MTBLS57 | MetaboLights
MetabolomicsEffects of Leuconostoc lactis on the antioxidant ability and indole-3-acetaldehyde metabolism via regulating the gut microbiota-liver axis in aged laying hens

Lactobacillus has antioxidant properties that may benefit poultry production. However, there is no systematic research on antioxidant of Lactobacillus strain and its effects on regulating nutrient metabolism in aged laying hens. This study investigated the influence of Leuconostoc lactis on produ...

2025-09-09 | MTBLS12964 | MetaboLights
MetabolomicsComparative metabolomic profiling and biological activities of Zygostelma benthamii Baill. (apocynaceae): unveiling organ-specific antioxidant, anti-inflammatory, and cytotoxic potentials

Zygostelma benthamii has been prized for its medicinal properties and is similar to ginseng. However, the specific chemicals in its various parts and their relationship to its therapeutic effects have not been thoroughly researched. Thus, we used a comprehensive metabolomics approach, LC-MS/MS an...

2026-07-29 | MTBLS15042 | MetaboLights
MetabolomicsMolecular profiling of sponge movement reveals an ancient contractile-inflammatory response

A hallmark of animals is the coordination of whole-body movement. Neurons and muscles are central to this; yet, coordinated movements also exist in sponges that lack these cell types. Sponges are sessile animals with a complex canal system for filter-feeding. They undergo whole-body movements res...

2026-08-11 | MTBLS8137 | MetaboLights
MetabolomicsEffect of heat stress on serum enzyme activity, antioxidant capacity and immune parameter metabolomics datasets in Holstein cows at different growth stages

Global climate change has led to an increase in release of atmospheric CO2 and average daily temperatures, making heat stress a major challenge in dairy farming. The present study aimed to investigate metabolite changes of Holstein cows at different stages. In this experiment, 10 growing heifers,...

2022-08-11 | MTBLS5148 | MetaboLights
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