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MetabolomicsExercise Activates Interferon Immune Response of the Liver via Gpld1 to Enhance Antiviral Innate Immunity

Healthy behavioral patterns could modulate organ functions to enhance the body’s immunity. However, whether exercise regulates antiviral innate immunity remains elusive. Here, we found that exercise promotes type-I IFN (IFN-I) production in the liver and enhances IFN-I immune activity of the body...

2024-04-24 | MTBLS7972 | MetaboLights
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
TranscriptomicsTranscription profiling of dendritic cells infected with Newcastle Disease Virus reveals that antiviral response is dictated by a choreographed cascade of transcription factors
The dendritic cell (DC) is a master regulator of immune responses. Pathogenic viruses subvert normal immune function in DCs through the expression of immune antagonists. Understanding how these antagonists interact with the host immune system requires knowledge of the underlying genetic regulatory n...
ORGANISM(S): Homo sapiens 
2010-03-08 | E-GEOD-18791 | biostudies-arrayexpress
TranscriptomicsPeroxisomes are signaling patforms for antiviral innate immunity
Analysis of the transcriptional response of mouse embryonic fibroblasts to reovirus infection. The hypothesis tested was that both peroxisomal and mitochondrial MAVS is capable of inducing the expression of antiviral genes. mRNA isolated from MAVS-expressing cells after infection for various times ...
ORGANISM(S): Mus musculus 
2010-11-04 | E-GEOD-21215 | biostudies-arrayexpress
GenomicsIdentification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses
This SuperSeries is composed of the following subset Series: GSE36241: Identification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (ChIP-Seq) GSE37051: Identification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (expression) Ref...
ORGANISM(S): Mus musculus 
2012-09-19 | E-GEOD-37052 | biostudies-arrayexpress
GenomicsIdentification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (ChIP-Seq)
We predict that a member of the forkhead family of transcription factors, FOXO3, is a negative regulator of a subset of antiviral genes. This prediction was validated using macrophages isolated from Foxo3-null mice. Genome-wide location analysis combined with gene deletion studies identified the Irf...
ORGANISM(S): Mus musculus 
2012-09-19 | E-GEOD-36241 | biostudies-arrayexpress
TranscriptomicsIdentification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (expression)
We have used an unbiased systems approach to predict that a member of the forkhead family of transcription factors, FOXO3, is a negative regulator of a subset of antiviral genes. This prediction was validated using macrophages isolated from Foxo3-null mice. We detected significantly increased transc...
ORGANISM(S): Mus musculus 
2012-09-19 | E-GEOD-37051 | biostudies-arrayexpress
TranscriptomicsA cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
Dendritic cells (DC) serve a key function in host defense, linking innate detection of microbes to the activation of pathogen-specific adaptive immune responses. Whether there is cell-intrinsic recognition of HIV-1 by host innate pattern-recognition receptors and subsequent coupling to antiviral T c...
ORGANISM(S): Homo sapiens 
2010-09-09 | E-GEOD-22589 | biostudies-arrayexpress
TranscriptomicsTranscription Factor Redundancy Ensures Induction of the Antiviral State
Transcriptional response to virus infection in mice lacking type I and type III signaling The transcriptional response to virus infection is thought to be predominantly induced by interferon (IFN) signaling. Here we demonstrate that, in the absence of IFN signaling, an IFN-like transcriptome is stil...
ORGANISM(S): Homo sapiens 
2010-10-15 | E-GEOD-24695 | biostudies-arrayexpress
ProteomicsInterferon Regulatory Factors: IRF1 and IRF7 directly regulate gene expression in bats in response to viral infection.
Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with IFNα signalling. Here we show IRF1,3 and 7 levels are elevated in most bat tissues and that basally, IRFs contribute to the expression of type I IFN ligands and high expression of Interferon Regula...
ORGANISM(S): Cellular Organisms 
2020-10-23 | PXD021982 | JPOST Repository
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