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TranscriptomicsTranscription Factor Redundancy Ensures Induction of the Antiviral State
Transcriptional response to virus infection in mice lacking type I and type III signaling The transcriptional response to virus infection is thought to be predominantly induced by interferon (IFN) signaling. Here we demonstrate that, in the absence of IFN signaling, an IFN-like transcriptome is stil...
ORGANISM(S): Homo sapiens 
2010-10-15 | E-GEOD-24695 | biostudies-arrayexpress
TranscriptomicsPeroxisomes are signaling patforms for antiviral innate immunity
Analysis of the transcriptional response of mouse embryonic fibroblasts to reovirus infection. The hypothesis tested was that both peroxisomal and mitochondrial MAVS is capable of inducing the expression of antiviral genes. mRNA isolated from MAVS-expressing cells after infection for various times ...
ORGANISM(S): Mus musculus 
2010-11-04 | E-GEOD-21215 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of dendritic cells infected with Newcastle Disease Virus reveals that antiviral response is dictated by a choreographed cascade of transcription factors
The dendritic cell (DC) is a master regulator of immune responses. Pathogenic viruses subvert normal immune function in DCs through the expression of immune antagonists. Understanding how these antagonists interact with the host immune system requires knowledge of the underlying genetic regulatory n...
ORGANISM(S): Homo sapiens 
2010-03-08 | E-GEOD-18791 | biostudies-arrayexpress
GenomicscGAS maintains basal antiviral state
cGAS maintains basal antiviral state
PRJNA839440 | ENA
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
TranscriptomicsTranscription profiling of human hepatocytes treated with 25-hydroxycholesterol and the antiviral state it conveys against the HCV
Hepatitis C virus (HCV) infection is a global health problem. A number of studies have implicated a direct role of cellular lipid metabolism in the HCV life cycle and inhibitors of the mevalonate pathway have been demonstrated to result in an antiviral state within the host cell. Transcriptome profi...
ORGANISM(S): Homo sapiens 
2009-01-02 | E-GEOD-14204 | biostudies-arrayexpress
TranscriptomicsHerpes simplex host shutoff attenuates antiviral state
Herpes simplex virus mutants lacking the vhs gene are severely attenuated in animal models of pathogenesis and exhibit reduced growth in primary cell culture. As a result of these properties vhs-deleted virus have been proposed as live-attenuated viruses. Despite these findings and their implication...
ORGANISM(S): Mus musculus 
2008-04-03 | E-GEOD-10962 | biostudies-arrayexpress
UnknownMeeting report: 32nd International Conference on Antiviral Research.
Not available
S-EPMC7105345 | biostudies-literature
TranscriptomicsTranscription profiling of wild type mouse embryonic fibroblasts treated with interferon to study interferon-regulated gene expression.
A number of IFN-induced proteins are believed to be responsible for the antiviral state induced by IFNs. Our microarray analysis of IFN-regulated genes in MEFs from wild-type mice identified 124 probe sets that were differentially regulated upon IFN treatment. This group consisted of many known ISGs...
ORGANISM(S): Mus musculus 
2007-10-12 | E-GEOD-3400 | biostudies-arrayexpress
GenomicsTranscription Factor Redundancy Ensures Induction of the Antiviral State
Transcription Factor Redundancy Ensures Induction of the Antiviral State
PRJNA132269 | ENA
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