Transcription profiling of wild type mouse embryonic fibroblasts treated with interferon to study interferon-regulated gene expression.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Lawrence Pfeffer
PROVIDER: E-GEOD-3400 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Role of nuclear factor-kappaB in the antiviral action of interferon and interferon-regulated gene expression.
Pfeffer Lawrence M LM Kim Jong-Gwan JG Pfeffer Susan R SR Carrigan Dennis J DJ Baker Darren P DP Wei Lai L Homayouni Ramin R
The Journal of biological chemistry 20040506 30
Interferons (IFNs) play critical roles in host defense by modulating the expression of various genes via tyrosine phosphorylation of STAT transcription factors. IFN-alpha/beta activates another important transcription factor, nuclear factor-kappaB (NF-kappaB), but its role in IFN-mediated activity is poorly understood. Sensitivity to the antiviral and gene-inducing effects of IFN was examined in normal fibroblasts and in NF-kappaB knockout fibroblasts from p50- and p65-null mice. Antiviral assay ...[more]
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This model is described in the article:
Stochastic Dynamics of Type I Interferon Responses
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PLOS Computational Biology, 2022
(*) Equally contributing authors
Abstract:
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