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TranscriptomicsThe effect of Heterogeneous Transcription Start Sites (TSS) on the Translatome: Implications for the Mammalian Cellular Phenotype.
Sequencing of total RNA and polysomal RNA of two cell lines, MCF7 (tumoral) and MCF10A (non-tumoral) Polysomal and total RNA was prepared from biological triplicates from the two cell lines. For each biological triplicate sub-confluent cell monolyers were lysed to produce cytoplasmic extracts. Half...
ORGANISM(S): Homo sapiens 
2015-11-24 | E-GEOD-74232 | biostudies-arrayexpress
GenomicsDown syndrome Data Access Committee (DS-DAC)
Data Access Committee EGAC01000000023
EGAC01000000023 | EGA
TranscriptomicsmicroRNA expression levels in human primary fibroblasts
MicroRNAs (miRNAs) are regulatory non-coding RNAs that affect the production of a significant fraction of human mRNAs via post-transcriptional regulation. Inter-individual variation of miRNA expression levels is likely to influence the expression of miRNA target genes, and may therefore contribute t...
ORGANISM(S): Homo sapiens 
2011-06-09 | E-GEOD-24610 | biostudies-arrayexpress
TranscriptomicsModelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21 [RNA-seq]
Down syndrome (trisomy 21) is the most common viable chromosomal disorder with intellectual impairment and several other developmental abnormalities. Here, we report the generation and characterization of induced pluripotent stem cells (iPSCs) derived from monozygotic twins discordant for trisomy 21...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-52249 | biostudies-arrayexpress
TranscriptomicsMethylation profiling in individuals with uniparental disomy identifies novel differentially methylated regions on chromosome 15
Methylation profiles of chr12-16 were generated by meDIP and array hybridisation in 3 cases with maternal uniparental disomy of chromosome 15, and three cases of paternal uniparental disomy of chromosome 15. Comparison of these profiles reveals differentially methylated (imprinted) regions on chromo...
ORGANISM(S): Homo sapiens 
2010-06-12 | E-GEOD-22188 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiles of human active and inactive X chromosomes
X chromosome inactivation (XCI) is a dosage compensation mechanism that silences the majority of genes on one X chromosome in each female cell. In order to characterize epigenetic changes that accompany this process, we measured DNA methylation levels in both 45,X Turner syndrome patients, who carry...
ORGANISM(S): Homo sapiens 
2010-07-20 | E-GEOD-22551 | biostudies-arrayexpress
GenomicsIdentification of cis- and trans-regulatory variation modulating microRNA expression levels in human fibroblasts
MicroRNAs (miRNAs) are regulatory noncoding RNAs that affect the production of a significant fraction of human mRNAs via post-transcriptional regulation. Interindividual variation of the miRNA expression levels is likely to influence the expression of miRNA target genes and may therefore contribute ...
EGAS00000000056 | EGA
TranscriptomicsMuscle transcriptome analysis of mouse models of partial trisomy and monosomy 21
Aneuploidies of human chromosome 21 (Down syndrome (DS) and monosomy 21 (M21)) lead to variable physiological abnormalities with constant mental retardation, locomotor deficits and altered muscle tone. To search for dosage-sensitive genes involved in DS and M21 phenotypes, we created two new mouse m...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-58463 | biostudies-arrayexpress
GenomicsEGAD00000000027
eQTL data for European newborns
EGAD00000000027 | EGA
GenomicsGencord Data Access Committee
Data Access Committee EGAC00001000105
EGAC00001000105 | EGA
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