Anxiety is an aggravating comorbidity of many psychiatric disorders that is often underdiagnosed and undertreated, and little is known on the mechanisms underlying its regulation. Here, we find that serum LPA16:0 abundance increases with trait anxiety in both humans and mice; while high LPA16:0 l...

for this association remains incompletely understood. Diabetes-associated genes have been implicated in the control of central nervous system (CNS) disorders. In the current study, we observed a significant downregulation of secretagogin (SCGN) across multiple organs in diabetic mouse models. Con...

Background The role of dietary interventions, particularly lysine-restricted diets(LRD), in mitigating obesity-associated anxiety-like behaviors remains poorly understood, with limited insight into gut microbiota-metabolite-brain axis mechanisms.

Results LRD significantly improved anxiety b...

Radiofrequency radiation (RFR) with specific parameters could alter brain function, yet the underlying mechanisms remain unclear. The gut-brain axis is reported to be important in regulating brain function. Therefore, this study used gut microbiota intervention, regulation of tryptophan metabolit...

Radiofrequency radiation (RFR) with specific parameters could alter brain function, yet the underlying mechanisms remain unclear. The gut-brain axis is reported to be important in regulating brain function. Therefore, this study used gut microbiota intervention, regulation of tryptophan metabolit...

A gut microbiota–20-HETE lipid signaling axis drives neuroinflammation and anxiety after TBI

Probiotic L. reuteri attenuates neuroinflammation and anxiety symptoms through gut-brain axis via a novel metabolite 20-HETE in blast-induced traumatic brain injury

Inflammatory bowel disease (IBD) is a chronic condition frequently accompanied by psychological comorbidities, such as anxiety and depression. Although current treatments may alleviate some of these symptoms, the intricate pathogenesis of these comorbidities highlights an urgent need for the deve...

The gut-brain axis facilitates two-way communication between gut inflammation and psychiatric comorbidities associated with inflammatory bowel disease (IBD). In this study, we examined the neuroprotective effects of the neuropeptide substance P (SP) on colitis. Taking into account the interaction...