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GenomicsIdentification of novel pathways regulated by APE1/Ref-1 in human retinal endothelial cells
Identification of novel pathways regulated by APE1/Ref-1 in human retinal endothelial cells
PRJNA900252 | ENA
ProteomicsProteomic changes following knockdown of DNA repair and redox signaling protein, APE1/Ref-1, under hypoxia conditions
Pancreatic cancer is a complex disease with a desmoplastic stroma, extreme hypoxia, and inherent resistance to therapy. Understanding the signaling and adaptive response of such an aggressive cancer is key to making advances in therapeutic efficacy and understanding disease progression. Redox factor...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020515 | Pride
Transcription factor signaling Ape1/ref-1 Dna repair Pancreatic cancer Hypoxia 
TranscriptomicsApurinic/apyrimidinic endonuclease/redox factor-1 (Ape1/Ref-1) activates Notch signaling through Jagged1 expression and promotes colon cancer progression
To investigate the possible role of Ape1/Ref-1 in tumorigenicity of colon cancer and explored the oncogenic mechanism of Ape1/Ref-1 in colon cancer cells.
ORGANISM(S): Homo sapiens 
2013-04-17 | GSE45912 | GEO
TranscriptomicsApurinic/apyrimidinic endonuclease/redox factor-1 (Ape1/Ref-1) activates Notch signaling through Jagged1 expression and promotes colon cancer progression
To investigate the possible role of Ape1/Ref-1 in tumorigenicity of colon cancer and explored the oncogenic mechanism of Ape1/Ref-1 in colon cancer cells. Control and Ref-1 overexpressing SW480cells, control and Ref-1-deficient SW480 cells. Duplicate
ORGANISM(S): Homo sapiens 
2013-04-17 | E-GEOD-45912 | biostudies-arrayexpress
UnknownDynamic Regulation of APE1/Ref-1 as a Therapeutic Target Protein.
Not available
S-EPMC4880582 | biostudies-literature
TranscriptomicsIdentification of novel pathways regulated by APE1/Ref-1 in human retinal endothelial cells
We used RNA seq tool to identfiy key signaling pathways affected by APE1/Ref-1 in HRECs, which was contrasted to RNA seq data of tumor cell lines.
ORGANISM(S): Homo sapiens 
2023-02-08 | GSE217746 | GEO
UnknownAntitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer.
Not available
S-EPMC6844258 | biostudies-literature
UnknownAlterations in Adipose Tissue and Adipokines in Heterozygous APE1/Ref-1 Deficient Mice.
Not available
S-EPMC11695485 | biostudies-literature
UnknownSubcellular localization of APE1/Ref-1 in human hepatocellular carcinoma: possible prognostic significance.
Not available
S-EPMC1869623 | biostudies-literature
UnknownATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1.
Not available
S-EPMC6651529 | biostudies-literature
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