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TranscriptomicsThe induced APL cells generated by the transplantation of PML-RARA-transduced human CD34+ hematopoietic cells into immunodeficient mice
A humanized in vivo APL model has been established utilizing the retroviral transduction of PML-RARA into human CD34+ hematopoietic cells and the transplantation of these cells into immunodeficient mice. The resultant leukemia recapitulated human APL phenotypically, and was clustered in the same cat...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-49344 | biostudies-arrayexpress
TranscriptomicsExpression data from PML-RARα transgenic mouse APL(acute promyelocyte leukemia) cells
The differentiation of leukemia stem cells (LSCs) is generally regarded as a one-way alterative process to self-renewal. However, how differentiation impacts LSC stemness has largely been unexplored. Here we show that before reaching terminal differentiation (TD), apical LSCs of mouse acute promyelo...
ORGANISM(S): Mus musculus 
2014-05-01 | E-GEOD-46094 | biostudies-arrayexpress
GenomicsDNA methylation changes are a late event in Acute Promyelocytic Leukemia and coincide with loss of transcription factor binding (sequencing)
The origin of aberrant DNA methylation in cancer remains largely unknown. In this study, we elucidated the DNA methylome in primary Acute Promyelocytic Leukemia (APL) and the role of PML-RARa in establishing these patterns. APL patients showed increased genome-wide DNA methylation with higher variab...
ORGANISM(S): Homo sapiens 
2012-11-08 | E-GEOD-42044 | biostudies-arrayexpress
GenomicsAPL nanopore sequencing
Nanopore sequencing for an APL patient
EGAS00001005618 | EGA
GenomicsPML-RARa/RXR alters the epigenetic landscape in Acute Promyelocytic Leukemia
Many different molecular mechanisms have been suggested to be associated with PML-RAR dependent transformation of haematopoietic progenitors. Here, we investigated the role of PML-RAR and RXR in the organization of epigenetic structures at a genome-wide level. We identified 2722 high confidence PML-...
ORGANISM(S): Homo sapiens 
2009-12-17 | E-GEOD-18886 | biostudies-arrayexpress
TranscriptomicsSNP data of acute promyelocytic leukemia samples
Acute promyelocytic leukemia (APL) is a hematopoietic malignant disease characterized by the chromosomal translocation t(15;17), resulting in the formation of the PML-RARA gene. Here, 47 t(15;17) APL samples were analyzed with high-density single-nucleotide polymorphism microarray (50K and 250K SNP...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-14016 | biostudies-arrayexpress
GenomicsProfiling of aPL response in mouse monocytes
Profiling of aPL response in mouse monocytes
PRJNA678738 | ENA
GenomicsAPL Oxford Nanopore sequencing - nanome
APL Oxford Nanopore sequencing
EGAS00001005613 | EGA
TranscriptomicsTargets of ALTERED PHLOEM DEVELOPMENT (APL)
We profiled transcripts from sorted phloem cells of wild-type and apl mutants to identify the genes regulated by APL in phloem. We profiled transcripts from sorted phloem cells of wild-type and apl mutants to identify the genes regulated by APL in phloem. Three biological replicates for control WT a...
ORGANISM(S): Arabidopsis thaliana 
2014-08-25 | E-GEOD-55222 | biostudies-arrayexpress
TranscriptomicsVariant acute promyelocytic leukemia (APL) bone marrow aCGH
CGH microarray in a patient with variant APL 1 sample hybridized to the Whole Human Genome CGH microarray 244K
ORGANISM(S): Homo sapiens 
2012-12-19 | E-GEOD-42984 | biostudies-arrayexpress
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