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TranscriptomicsTranscriptional Profiling of Neuronal APP/APLP2 Double-Conditional Knockout Mice.
Gene expression analysis of 2-month-old APP/APLP2 double-conditional Knockout (N-dCKO) mice and littermate APLP2 knockout controls, APP knockout and wildtype controls. Mouse hippocampus were dissected for RNA extraction and hybridization on Affymetrix microarrays.
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-48622 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome analysis of APPs?-DM and APLP2-KO brains
Despite its key role in Alzheimer pathogenesis, the physiological function(s) of the amyloid precursor protein (APP) and of its proteolytic fragments are still poorly understood. The secreted APPs? ectodomain has been shown to be involved in neuroprotection and synaptic plasticity. The ?-secretase g...
ORGANISM(S): Mus musculus 
2011-05-10 | E-GEOD-27888 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiling of Neuronal APP/APLP2 Double-Conditional Knockout Mice.
Gene expression analysis of 2-month-old APP/APLP2 double-conditional Knockout (N-dCKO) mice and littermate APLP2 knockout controls, APP knockout and wildtype controls.
ORGANISM(S): Mus musculus 
2013-07-10 | GSE48622 | GEO
TranscriptomicsComparative transcriptome analysis of APPsα-DM and APLP2-KO brains
Despite its key role in Alzheimer pathogenesis, the physiological function(s) of the amyloid precursor protein (APP) and of its proteolytic fragments are still poorly understood. The secreted APPsα ectodomain has been shown to be involved in neuroprotection and synaptic plasticity. The γ-secretase g...
ORGANISM(S): Mus musculus 
2011-05-10 | GSE27888 | GEO
UnknownHippocampal network oscillations in APP/APLP2-deficient mice.
Not available
S-EPMC3621758 | biostudies-literature
UnknownAPLP2 Modulates JNK-Dependent Cell Migration in Drosophila.
Not available
S-EPMC6093063 | biostudies-literature
UnknownAPLP2 Regulates Refractive Error and Myopia Development in Mice and Humans.
Not available
S-EPMC4551475 | biostudies-literature
UnknownAPPsα rescues impaired Ca2+ homeostasis in APP- and APLP2-deficient hippocampal neurons.
Not available
S-EPMC8256088 | biostudies-literature
UnknownAPLP2 regulates the expression of MHC class I molecules on irradiated Ewing's sarcoma cells.
Not available
S-EPMC3862638 | biostudies-literature
UnknownAmyloid-precursor Like Proteins APLP1 and APLP2 Are Dispensable for Normal Development of the Neonatal Respiratory Network.
Not available
S-EPMC5479907 | biostudies-literature
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