Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ulrike Müller
PROVIDER: E-GEOD-27888 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The EMBO journal 20110426 11
Despite its key role in Alzheimer pathogenesis, the physiological function(s) of the amyloid precursor protein (APP) and its proteolytic fragments are still poorly understood. Previously, we generated APPsα knock-in (KI) mice expressing solely the secreted ectodomain APPsα. Here, we generated double mutants (APPsα-DM) by crossing APPsα-KI mice onto an APLP2-deficient background and show that APPsα rescues the postnatal lethality of the majority of APP/APLP2 double knockout mice. Surviving APPsα- ...[more]