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MetabolomicsSingle-cell RNA sequencing decipher hepatic injury and APOA4 as a biomarker in males with intrauterine growth restriction

Intrauterine growth restriction (IUGR) is associated with increased relative liver weight at birth, hepatic function decline and a higher risk for chronic liver and cardiovascular diseases in adults. Precise mechanisms of early developmental plasticity to intervene in poor fetal programming and a...

2023-09-25 | MTBLS6881 | MetaboLights
GenomicsATF3 regulates hepatic ApoA4 upon metabolic stress
ATF3 regulates hepatic ApoA4 upon metabolic stress
PRJNA1217852 | ENA
UnknownA long non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR in mice.
Not available
S-EPMC5291254 | biostudies-literature
TranscriptomicsATF3 regulates hepatic ApoA4 upon metabolic stress
The liver plays essential roles in maintaining systemic glucolipid homeostasis under ever changing metabolic stressors. Metabolic dysregulation can lead to both adaptive and maladaptive changes that impact systemic physiology. Here we examined disparate genetic and environmental metabolic stressors ...
ORGANISM(S): Mus musculus 
2025-02-02 | GSE288486 | GEO
GenomicsRNA sequencing reveals effect of Apoa4 on kidney cells from mice with diet-induced obesity
RNA sequencing reveals effect of Apoa4 on kidney cells from mice with diet-induced obesity
PRJNA1148386 | ENA
TranscriptomicsRNA sequencing reveals effect of Apoa4 on kidney cells from mice with diet-induced obesity
Metabolic inflammation induced by obesity accelerate the progression of chronic kidney disease (CKD). During this progression, immune microenvironment plays important role. ApoA4 deficiency increases the kidney disorder of metabolism and immune and kidney injury. This study aimed to profile the rena...
ORGANISM(S): Mus musculus 
2026-09-21 | GSE274873 | GEO
UnknownSerum APOA4 Pharmacodynamically Represents Administered Recombinant Human Hepatocyte Growth Factor (E3112).
Not available
S-EPMC8123842 | biostudies-literature
TranscriptomicsSingle-cell RNA sequencing reveals effect of Apoa4 on kidney cells from mice with diet-induced obesity
Metabolic inflammation induced by obesity accelerate the progression of chronic kidney disease (CKD). During this progression, immune microenvironment plays important role. However, the precise subsets of immune cell that exacerbate kidney injury remain elusive. ApoA4 deficiency increases the kidney...
ORGANISM(S): Mus musculus 
2026-09-21 | GSE272641 | GEO
UnknownEffect of ApoA4 on SERPINA3 mediated by nuclear receptors NR4A1 and NR1D1 in hepatocytes.
Not available
S-EPMC5956904 | biostudies-literature
GenomicsSingle-cell RNA sequencing reveals a novel inhibitory effect of ApoA4 on NAFL mediated by liver-specific subsets of myeloid cells
Single-cell RNA sequencing reveals a novel inhibitory effect of ApoA4 on NAFL mediated by liver-specific subsets of myeloid cells
PRJNA875932 | ENA
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