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TranscriptomicsGenome-wide identification and functional analysis of Apobec-1 mediated C-to-U RNA editing in mouse small intestine and liver
The genome-wide identification, tissue-specificity and functional implications of Apobec-1 mediated C-to-U RNA editing remains incomplete. Deep sequencing, data filtering and validation from wild-type and Apobec-1 deficient mice revealed 56 novel editing sites in 54 intestinal mRNAs and 22 novel sit...
ORGANISM(S): Mus musculus 
2014-05-23 | E-GEOD-57910 | biostudies-arrayexpress
Proteomics,MultiomicsAPOBEC3A is an Oral Cancer Prognostic Biomarker in Taiwanese Carriers of an APOBEC Deletion Polymorphism
Chen T-W, Lee C-C, Liu H, Wu C-S, Pickering CR, Huang P-J, et al., Nature Communications 8, Article number: 465 (2017) doi:10.1038/s41467-017-00493-9

Oral squamous cell carcinoma is a prominent cancer worldwide, p...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-08-28 | MSV000084250 | MassIVE
ProteomicsGenome-wide identification and functional analysis of Apobec-1 mediated C-to-U RNA editing in mouse small intestine and liver
Background: RNA editing encompasses a post-transcriptional process in which the genomically templated sequence is enzymatically altered and introduces a modified base into the edited transcript. Mammalian C-to-U RNA editing represents a distinct subtype of base modification, whose prototype is inte...
ORGANISM(S): Mus musculus (Mouse) 
2014-06-02 | PXD001007 | Pride
Intestine Rna editing Polysomes Liver 
GenomicsAPOBEC Cytidine Deaminase Mutagenesis Pattern is Widespread in Human Cancers
APOBEC Cytidine Deaminase Mutagenesis Pattern is Widespread in Human Cancers
PRJNA226256 | ENA
ProteomicsAPOBEC mutagenesis and copy number alterations are drivers of proteogenomic tumor evolution and heterogeneity in metastatic thoracic tumors
Intratumor mutational heterogeneity has been documented in primary non-small cell lung cancer. Here, we elucidate mechanisms of tumor evolution and heterogeneity in metastatic thoracic tumors (lung adenocarcinoma and thymic carcinoma) using whole-exome and transcriptome sequencing, SNP array for cop...
ORGANISM(S): Homo sapiens (Human) 
2019-05-07 | PXD012845 | Pride
Proteomics Tumor heterogeneity rapid autopsy 
UnknownHypermutation of ApoB mRNA by rat APOBEC-1 overexpression mimics APOBEC-3 hypermutation.
Not available
S-EPMC3311742 | biostudies-literature
GenomicsAPOBEC mutagenesis, kataegis, chromothripsis in EGFR-mutant osimertinib-resistant lung adenocarcinomas
APOBEC mutagenesis, kataegis, chromothripsis in EGFR-mutant osimertinib-resistant lung adenocarcinomas
PRJNA1173788 | ENA
GenomicsAPOBEC mutagenesis, kataegis, chromothripsis in EGFR-mutant osimertinib-resistant lung adenocarcinomas
APOBEC mutagenesis, kataegis, chromothripsis in EGFR-mutant osimertinib-resistant lung adenocarcinomas
PRJNA1173789 | ENA
Genomics
APOBEC mutagenesis
PRJNA1231511 | ENA
UnknownFHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis.
Not available
S-EPMC4413662 | biostudies-literature
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