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GenomicsProspectively-defined patterns of APOBEC3A mutagenesis are prevalent in human cancers
APOBEC3A mutagenesis
PRJEB50626 | ENA
GenomicsAPOBEC3A-mediated tRNA editing in vitro
YAMAT-seq analysis of APOBEC3A-mediated tRNA deamination in vitro
PRJEB108328 | ENA
Proteomics,MultiomicsAPOBEC3A is an Oral Cancer Prognostic Biomarker in Taiwanese Carriers of an APOBEC Deletion Polymorphism
Chen T-W, Lee C-C, Liu H, Wu C-S, Pickering CR, Huang P-J, et al., Nature Communications 8, Article number: 465 (2017) doi:10.1038/s41467-017-00493-9

Oral squamous cell carcinoma is a prominent cancer worldwide, p...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-08-28 | MSV000084250 | MassIVE
GenomicsAPOBEC3A induces cancer-specific mutational signatures in human genomes
APOBEC3A induces cancer-specific mutational signatures in human genomes
PRJEB13145 | ENA
GenomicsRNA editing enzyme APOBEC3A promotes pro-inflammatory (M1) macrophage polarization
RNA editing enzyme APOBEC3A promotes pro-inflammatory (M1) macrophage polarization
PRJNA612213 | ENA
GenomicsGenomic landscape of DNA methylation following APOBEC3A-induced mutation
Genomic landscape of DNA methylation following APOBEC3A-induced mutation
PRJNA803047 | ENA
UnknownAPOBEC3A suppresses cervical cancer via apoptosis.
Not available
S-EPMC10647198 | biostudies-literature
TranscriptomicsRNA editing enzyme APOBEC3A promotes pro-inflammatory (M1) macrophage polarization
Macrophages acquire a pro-inflammatory M1 phenotype in response to microbial products or pro-inflammatory cytokines through incompletely understood molecular mechanisms. We recently described the induction of APOBEC3A-mediated cellular site-specific cytosine-to-uracil (C>U) RNA editing during M1 mac...
ORGANISM(S): Homo sapiens 
2020-03-13 | GSE146867 | GEO
ProteomicsInteraction with the CCT chaperonin complex limits cytotoxicity from the APOBEC3A cytosine deaminase.
The APOBEC3 cytosine deaminases are implicated as the cause of a prevalent somatic mutation pattern found in cancer genomes. The APOBEC3 enzymes act as viral restriction factors by mutating viral genomes. Mutation of the cellular genome is presumed to be an off-target activity of the enzymes, althou...
ORGANISM(S): Homo sapiens (Human) 
2021-07-02 | PXD024191 | Pride
Protein interaction Cct chaperonin Cytosine deaminase Apobec3a Mutational signatures 
UnknownAPOBEC3A catalyzes mutation and drives carcinogenesis in vivo.
Not available
S-EPMC7953736 | biostudies-literature
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