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ProteomicsAPEX2 of BAX, BAK and DRP1 in healthy and apoptotic cells
To identify components of mitochondrial apoptotic foci, Flag-APEX2-tagged constructs targeting Bax, Bak, and Drp1 were generated. These constructs are designed to localize to foci at the mitochondrial outer membrane (MOM) during apoptosis. Following biotinylation with BP and H2O2, quantitative mass ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-27 | PXD055201 | Pride
Bak Apex2 Bax Apoptotic foci Drp1 
UnknownA minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks.
Not available
S-EPMC2872460 | biostudies-literature
TranscriptomicsFish oil/pectin temporally alters gene expression profiles in exfoliated rat colonocytes throughout oncogenesis
We have demonstrated that fish oil/pectin (FO/P) diets protect against colon cancer compared to corn oil/cellulose (CO/C) by upregulating apoptosis and suppressing proliferation. To elucidate the mechanisms whereby FO/P diets induce apoptosis and suppress proliferation during the tumorigenic process...
ORGANISM(S): Rattus norvegicus 
2012-02-20 | E-GEOD-27266 | biostudies-arrayexpress
TranscriptomicsDUX4-induced dsRNA and MYC mRNA Stabilization Activate Apoptotic Pathways in Human Cell Models of Facioscapulohumeral Dystrophy
Facioscapulohumeral muscular dystophy (FSHD) is caused by the mis-expression of DUX4 in skeletal muscle cells. DUX4 is a transcription factor that activates genes normally associated with stem cell biology and its mis-expression in FSHD cells results in apoptosis. To identify genes and pathways nece...
ORGANISM(S): Homo sapiens 
2016-12-31 | GSE87495 | GEO
UnknownThe SUMO ligase PIAS1 regulates UV-induced apoptosis by recruiting Daxx to SUMOylated foci.
Not available
S-EPMC3575712 | biostudies-literature
UnknownHeat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response.
Not available
S-EPMC3420188 | biostudies-literature
UnknownQuercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis.
Not available
S-EPMC2714375 | biostudies-literature
UnknownDUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy.
Not available
S-EPMC5362247 | biostudies-literature
UnknownBax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores.
Not available
S-EPMC4755116 | biostudies-literature
UnknownATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress.
Not available
S-EPMC2607051 | biostudies-literature
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