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ProteomicsVDAC2 promotes BAX apoptotic activity
Intrinsic apoptosis is critical for normal physiology including the prevention of tumor formation. BAX and BAK, which are essential for mediating this process and for the cytotoxic action of many anti-cancer drugs, are thought to be regulated through similar mechanisms and act redundantly to drive a...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-29 | PXD011195 | Pride
Cancer Bak Bax Mitochondria Voltage-dependent anion channel. Bcl-2 Apoptosis 
ProteomicsCovalent Inhibition of Pro-Apoptotic BAX
BCL-2-associated X protein (BAX) is a promising therapeutic target for activating or restraining apoptosis in diseases of pathologic cell survival or cell death, respectively. In response to cellular stress, BAX transforms from a quiescent cytosolic monomer into a toxic oligomer that permeabilizes t...
ORGANISM(S): Homo sapiens (Human) 
2024-01-19 | PXD040917 | Pride
Bax  hdx-ms  hydrogen/deuterium exchange mass spectrometry  covalent inhibitor 
ProteomicsThe Conformational Stability of Pro-apoptotic BAX is Dictated by Discrete Residues of the Protein Core
BAX is a pro-apoptotic member of the BCL-2 family, which regulates the balance between cellular life and death. During homeostasis, BAX predominantly resides in the cytosol as a latent monomer but, in response to stress, transforms into an oligomeric protein that permeabilizes the mitochondria, lead...
ORGANISM(S): Homo sapiens (Human) 
2021-08-26 | PXD024479 | Pride
Bcl-2 protein Hdxms Bax Hydrogen deuterium exchange Apoptosis 
ProteomicsDiscovery of an Enantioselective Covalent Inhibitor of BAX for Cytoprotection in Vivo
The pro-apoptotic BCL-2 protein BAX is a central executioner of mitochondrial apoptosis and a driver of acute and chronic cell loss in diverse human diseases. The C126 residue of BAX lies within a key regulatory region and its derivatization by physiologic and pharmacologic ligands can alternatively...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-28 | PXD069506 | Pride
Bax  hdx-ms  hydrogen/deuterium exchange mass spectrometry  covalent inhibitor 
ProteomicsInteractome of activated BAX in Senescent Cells.
We aimed to identify the interactome of activated BAX in the mitochondria of senescent cells. Our goal was to understand which factors can directly mediate the formation of BAX pores in senescent cells.
ORGANISM(S): Homo sapiens (Human) 
2023-08-13 | PXD040018 | Pride
Mtdna Cellular senescence Bax Mitochondria 
GenomicsscRNA-seq of E14 Bax null, Atoh7 null, and Bax null/Atoh7 null retinas
scRNA-seq of E14 Bax null, Atoh7 null, and Bax null/Atoh7 null retinas
PRJNA625890 | ENA
TranscriptomicsTranscription profiling of mouse Bax null versus NGF-Bax double null animals
We report that developmental competition between sympathetic neurons for survival is critically dependent on a sensitization process initiated by target innervation and mediated by a series of feedback loops. Target-derived nerve growth factor (NGF) promoted expression of its receptor TrkA in neur...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10498 | biostudies-arrayexpress
ProteomicsInhibition of Oligomeric BAX by an Anti-Apoptotic Dimer
BAX is a pro-apoptotic BCL-2 protein that resides in the cytosol as a monomer until triggered by cellular stress to transform into an oligomer that permeabilizes the mitochondria and induces apoptosis. We previously reported the generation of a full-length BAX oligomer (BAXO) that recapitulates pro-...
ORGANISM(S): Homo sapiens (Human) 
2025-11-21 | PXD049315 | Pride
Bcl-w  bax  bcl-w dimer  bax oligomer  hdx-ms  hydrogen/deuterium exchange mass spectrometry  apoptotic regulation 
TranscriptomicsWild type mouse embryonic fibroblasts (MEF) vs Bax/BAK double knock out MEF treated with and without Nocodazole
MEF WT, MEF DKO(Bax/Bak), MEF DKO(Bax/Bak) expressing rabbit Serca2a, MEF DKO(Bax/Bak) expressing Bak at the endoplasmic reticulum both control and treated with Noco 100 nM for 48h
ORGANISM(S): Mus musculus 
2023-06-12 | E-MTAB-10997 | biostudies-arrayexpress
ProteomicsChemical and photo-Crosslinking experiments of the BAX/BNIP3/PeptideB interaction
In these experiments we try to show by cross-linking MS how BAX and BNIP3 interact (DSSO cross-linking) and how Peptide B (an octapeptide that prevents mitochondrial damage and cell death induced by BNIP3/BAX activity) interacts with the BNIP3/BAX complex (BPA cross-linking; BPA on Peptide B).
ORGANISM(S): Homo sapiens (Human) 
2026-05-22 | PXD056758 | Pride
Bnip3 Bax Mitochondrial damage Cell death 
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