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ProteomicsIdentification of NIX-GST and BNIP3-GST interactors
We aimed to identify proteins that interact with the mitophagy receptors NIX or BNIP3. To this end, we incubated recombinantly purified NIX-GST or BNIP3-GST with HeLa cell lysate to identify proteins that would bind to NIX and BNIP3.
ORGANISM(S): Homo sapiens (Human) 
2025-01-30 | PXD060351 | Pride
Mitophagy Wipi2 Bnip3 Pull-down Nix 
ProteomicsChemical and photo-Crosslinking experiments of the BAX/BNIP3/PeptideB interaction
In these experiments we try to show by cross-linking MS how BAX and BNIP3 interact (DSSO cross-linking) and how Peptide B (an octapeptide that prevents mitochondrial damage and cell death induced by BNIP3/BAX activity) interacts with the BNIP3/BAX complex (BPA cross-linking; BPA on Peptide B).
ORGANISM(S): Homo sapiens (Human) 
2026-05-22 | PXD056758 | Pride
Bnip3 Bax Mitochondrial damage Cell death 
GenomicsGene expression of wild-type and Nix-/-Bnip3-/- memory B cells
Gene expression of wild-type and Nix-/-Bnip3-/- memory B cells
PRJNA734633 | ENA
ProteomicsIdentification of global proteome changes upon rapalog-induced tethering of WIPI2 to the mitochondrial outer membrane in wild-type or NIX/BNIP3 DKO HeLa cells
We aimed to identify proteins that would be turned over upon artificial tethering of WIPI2 to the mitochondrial surface upon rapalog treatment, using the FIS1-FRB plus FKBP-GFP-WIPI2 tethering system. We had previously observed that this induces mitophagy based on flow cytometry analysis of the mt-m...
ORGANISM(S): Homo sapiens (Human) 
2025-01-30 | PXD060363 | Pride
Mitophagy Wipi2 Bnip3 Hypoxia Mitochondria Nix 
ProteomicsPPTC7 integrates homeostatic and physiological signals to regulate mitophagy and mitochondrial mass
Here we report that knockout of PPTC7, a mitochondrial matrix protein, hyperactivates BNIP3/NIX-mediated mitophagy in vitro and in vivo. Biochemically, the PPTC7 precursor is trapped by BNIP3 and NIX to mitochondrial outer-membrane, where PPTC7 scaffolds the assembly of the substrate-PPTC7- SCFFBXL4...
ORGANISM(S): Homo Sapiens 
PXD042744 |
TranscriptomicsGene expression of wild-type and Nix-/-Bnip3-/- memory B cells
Memory B cells are long-lived lymphocytes essential for humoral immunological memory. Autophagy is required for the long-term survival of memory B cells, however, the molecular mechanisms for the protection by autophagy have not been fully elucidated. Here we show that mitochondrial autophagy mediat...
ORGANISM(S): Mus musculus 
2021-06-03 | GSE176047 | GEO
ProteomicsDNA damage response signaling to mitochondria drives senescence
Cellular senescence is a stress-induced permanent cell cycle arrest typically accompanied by expression of the cyclin-dependent kinase inhibitor p16. Recent studies have suggested that p16-expressing senescent cells accumulate in the body with age and play a causative role in aging. Various stresses...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD036980 | Pride
Human Lc-ms/ms 
UnknownEIF4A3-Induced circ-BNIP3 Aggravated Hypoxia-Induced Injury of H9c2 Cells by Targeting miR-27a-3p/BNIP3.
Not available
S-EPMC6951839 | biostudies-literature
GenomicsIdentification of SRSF9 through pooled shRNA screening links BNIP3 splicing to autophagy and metabolic reprogramming in breast cancer
Identification of SRSF9 through pooled shRNA screening links BNIP3 splicing to autophagy and metabolic reprogramming in breast cancer
PRJNA1248513 | ENA
TranscriptomicsIdentification of SRSF9 through pooled shRNA screening links BNIP3 splicing to autophagy and metabolic reprogramming in breast cancer
Autophagy is a catabolic process that facilitates the degradation of toxic molecules and contributes to the maintenance of cellular homeostasis. However, the alternative splicing of genes involved in hypoxia-induced autophagy remains relatively unexplored. Here we performed pooled shRNA screening of...
ORGANISM(S): Homo sapiens 
2025-07-11 | GSE294174 | GEO
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