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TranscriptomicsTranscription profiling of mouse spleens of wild type mice and mutants lacking Nix, a proapoptotic BH3-only factor that is transcriptionally induced during erythropoiesis
Normal erythropoiesis requires a critical balance between proapoptotic and antipaoptotic pathways. Bcl-xl, an antiapoptotic protein is induced at end-stages of differentiation of erythroid precursors in response to erythropoietin. The details of the proapoptotic pathway and the critical proapoptotic...
ORGANISM(S): Mus musculus 
2007-11-07 | E-GEOD-7020 | biostudies-arrayexpress
ProteomicsIdentification of NIX-GST and BNIP3-GST interactors
We aimed to identify proteins that interact with the mitophagy receptors NIX or BNIP3. To this end, we incubated recombinantly purified NIX-GST or BNIP3-GST with HeLa cell lysate to identify proteins that would bind to NIX and BNIP3.
ORGANISM(S): Homo sapiens (Human) 
2025-01-30 | PXD060351 | Pride
Mitophagy Wipi2 Bnip3 Pull-down Nix 
ProteomicsNix Interacts with WIPI2 to Induce Mitophagy
Determining what autophagy proteins bind to the MER domain of Nix
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-30 | MSV000092324 | MassIVE
GenomicsGene expression of wild-type and Nix-/-Bnip3-/- memory B cells
Gene expression of wild-type and Nix-/-Bnip3-/- memory B cells
PRJNA734633 | ENA
TranscriptomicsThe molecular consequences of Nix ablation on apoptosis and erythropoiesis
Normal erythropoiesis requires a critical balance between proapoptotic and antipaoptotic pathways. Bcl-xl, an antiapoptotic protein is induced at end-stages of differentiation of erythroid precursors in response to erythropoietin. The details of the proapoptotic pathway and the critical proapoptotic...
ORGANISM(S): Mus musculus 
2007-02-14 | GSE7020 | GEO
TranscriptomicsGene expression of wild-type and Nix-/-Bnip3-/- memory B cells
Memory B cells are long-lived lymphocytes essential for humoral immunological memory. Autophagy is required for the long-term survival of memory B cells, however, the molecular mechanisms for the protection by autophagy have not been fully elucidated. Here we show that mitochondrial autophagy mediat...
ORGANISM(S): Mus musculus 
2021-06-03 | GSE176047 | GEO
ProteomicsIdentification of global proteome changes upon rapalog-induced tethering of WIPI2 to the mitochondrial outer membrane in wild-type or NIX/BNIP3 DKO HeLa cells
We aimed to identify proteins that would be turned over upon artificial tethering of WIPI2 to the mitochondrial surface upon rapalog treatment, using the FIS1-FRB plus FKBP-GFP-WIPI2 tethering system. We had previously observed that this induces mitophagy based on flow cytometry analysis of the mt-m...
ORGANISM(S): Homo sapiens (Human) 
2025-01-30 | PXD060363 | Pride
Mitophagy Wipi2 Bnip3 Hypoxia Mitochondria Nix 
ProteomicsPPTC7 integrates homeostatic and physiological signals to regulate mitophagy and mitochondrial mass
Here we report that knockout of PPTC7, a mitochondrial matrix protein, hyperactivates BNIP3/NIX-mediated mitophagy in vitro and in vivo. Biochemically, the PPTC7 precursor is trapped by BNIP3 and NIX to mitochondrial outer-membrane, where PPTC7 scaffolds the assembly of the substrate-PPTC7- SCFFBXL4...
ORGANISM(S): Homo Sapiens 
PXD042744 |
UnknownNix interacts with WIPI2 to induce mitophagy.
Not available
S-EPMC10646555 | biostudies-literature
UnknownNix-mediated mitophagy regulates platelet activation and life span.
Not available
S-EPMC6693007 | biostudies-literature
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