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GenomicsExpression data of Hep3b cells transfected with si-WIPI2 and si-NC
Expression data of Hep3b cells transfected with si-WIPI2 and si-NC
PRJNA587165 | ENA
UnknownNix interacts with WIPI2 to induce mitophagy.
Not available
S-EPMC10646555 | biostudies-literature
UnknownSTING directly recruits WIPI2 for autophagosome formation during STING-induced autophagy.
Not available
S-EPMC10106988 | biostudies-literature
TranscriptomicsExpression data of Hep3b cells transfected with si-WIPI2 and si-NC
WIPI2 regulates the growth of human liver cancer cells. We used microarray to detail the global program of gene expression underlying the cell growth of human liver cancer cell line Hep3b cells.
ORGANISM(S): Homo sapiens 
2021-11-01 | GSE139865 | GEO
ProteomicsIdentification of global proteome changes upon rapalog-induced tethering of WIPI2 to the mitochondrial outer membrane in wild-type or NIX/BNIP3 DKO HeLa cells
We aimed to identify proteins that would be turned over upon artificial tethering of WIPI2 to the mitochondrial surface upon rapalog treatment, using the FIS1-FRB plus FKBP-GFP-WIPI2 tethering system. We had previously observed that this induces mitophagy based on flow cytometry analysis of the mt-m...
ORGANISM(S): Homo sapiens (Human) 
2025-01-30 | PXD060363 | Pride
Mitophagy Wipi2 Bnip3 Hypoxia Mitochondria Nix 
UnknownA PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy.
Not available
S-EPMC7337497 | biostudies-literature
UnknownWIPI2 enhances the vulnerability of colorectal cancer cells to erastin via bioinformatics analysis and experimental verification.
Not available
S-EPMC10189881 | biostudies-literature
UnknownA mutation in the major autophagy gene, WIPI2, associated with global developmental abnormalities.
Not available
S-EPMC6487338 | biostudies-literature
UnknownSuppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation.
Not available
S-EPMC6844494 | biostudies-literature
ProteomicsNix Interacts with WIPI2 to Induce Mitophagy
Determining what autophagy proteins bind to the MER domain of Nix
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-30 | MSV000092324 | MassIVE
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