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TranscriptomicsTranscription profiling of mouse models of sepsis cecal ligation and puncture and tracheal instillation of P. aeruginosa reveals bcl-2 overexpression modulates transcription responses in vivo
Background: We hypothesized that spleen microarray gene expression profiles analyzed with contemporary pathway analysis software would provide molecular pathways of interest and target genes that might help explain the affect of bcl-2 on improving survival during sepsis. Methods: Two mouse models of...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5811 | biostudies-arrayexpress
ProteomicsDevelopment and crystal structures of a more potent second-generation dual degrader of BCL-2 and BCL-xL
Overexpression of BCL-xL and BCL-2 play key roles in tumorigenesis and cancer drug resistance. Advances in PROTAC technology facilitated recent development of the first BCL-xL/BCL-2 dual degrader, 753b, a VHL-based degrader with improved potency and reduced toxicity compared to previous small molec...
ORGANISM(S): Homo sapiens (Human) 
2024-03-12 | PXD049976 | Pride
Protac Crystal structure Ubiquitin Ternary complex Degrader E3 ligase Bcl-xl/bcl-2 
ProteomicsStructural Insights into Chemoresistance Mutants of BCL-2 and their Targeting by Stapled BAD BH3 Helices
BCL-2 is a central regulator of apoptosis that inhibits cell death by sequestering pro-apoptotic BH3 alpha-helices within a hydrophobic surface groove. While venetoclax, a BH3-mimetic drug, has transformed the treatment of BCL-2–driven malignancies, its efficacy is increasingly limited by acquired r...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD062817 | Pride
Bcl-2 Venetoclax Bh3 inhibition Resistance mutation Hydrogen/deuterium exchange mass spectrometry Apoptotic regulation Bad Hdx-ms Stapled peptide 
TranscriptomicsTranscription profiling of human SCLC cell line set 2
RNA expression analysis was performed to compare patterns to sensitivity to BCL2 inhibitors (ABT-263). Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL and Mcl-1) is commonly associated with tumor maintenance, progression and chemoresistance. We previously reported the discover...
ORGANISM(S): Homo sapiens 
2008-06-19 | E-GEOD-10841 | biostudies-arrayexpress
TranscriptomicsABT-737 treatment induces regulation and activation of pathways implicated in cell survival, proliferation and stem cells in treated AML mice survival, proliferation and stem cells in treated AML mice
Myelodysplastic syndrome (MDS) transforms into an acute myelogenous leukemia (AML) with associated increased bone marrow blast infiltration. Using a transgenic mouse model, MRP8[NRASD12/hBCL-2], in which the NRAS:BCL-2 complex at the mitochondria induces MDS progressing to AML with dysplastic featur...
ORGANISM(S): Mus musculus 
2013-11-06 | E-GEOD-48601 | biostudies-arrayexpress
ProteomicsDevelopment and crystal structures of a more potent second-generation dual degrader of BCL-2 and BCL-xL
Overexpression of BCL-xL and BCL-2 play key roles in tumorigenesis and cancer drug resistance. Advances in PROTAC technology facilitated recent development of the first BCL-xL/BCL-2 dual degrader, 753b, a VHL-based degrader with improved potency and reduced toxicity compared to previous small molec...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-21 | MSV000094144 | MassIVE
GenomicsConditional Fibroblast BCL-2 Expression Promotes Persistent Pulmonary Fibrosis, which is Reversible by Therapeutic BCL-2 Inhibition
Conditional Fibroblast BCL-2 Expression Promotes Persistent Pulmonary Fibrosis, which is Reversible by Therapeutic BCL-2 Inhibition
PRJNA1327920 | ENA
GenomicsBcl-2 overexpression effects in rat neural precursor cells.
Bcl-2 overexpression effects in rat neural precursor cells.
PRJNA540436 | ENA
ProteomicsComplementary Backbone and Side-chain Analysis of Drug – Protein Interactions: Combining Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting to Discriminate the Binding of Small Molecule Therapeutics
Characterizing and distinguishing protein-ligand interactions is crucial for understanding cellular metabolism and guiding drug discovery and development. We employ hydrogen/deuterium exchange mass spectrometry (HDX-MS) and a new Fenton chemistry-based approach to protein oxidative mass spectrometry...
ORGANISM(S): Homo sapiens (Human) 
2026-03-27 | PXD050663 | Pride
Hdx Ox-ms Bcl2 Binding 
GenomicsBCL-2 pathway counteracts aneuploidy in mammalian embryos
BCL-2 pathway counteracts aneuploidy in mammalian embryos
PRJEB36524 | ENA
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