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UnknownPhysical Interventions Restore Physical Frailty and the Expression of CXCL-10 and IL-1β Inflammatory Biomarkers in Old Individuals and Mice.
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S-EPMC10886745 | biostudies-literature
TranscriptomicsInduction of pluripotency in human cord blood unrestricted somatic stem cells
Induced pluripotent stem (iPS) cells have been generated from mouse and human somatic cells by ectopic expression of the transcription factors OCT4, SOX2, KLF4, c-MYC as well as NANOG and LIN28. Here we report generation of induced pluripotent stem cells from human umbilical cord blood derived unres...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-20532 | biostudies-arrayexpress
TranscriptomicsHuman PGC commitment shares key gene dynamics to mouse, but owns a unique PRDM14 expression pattern
The molecular mechanisms of human primordial germ cell (PGC) specification are poorly understood due to the inaccessibility of cell materials and the lack of an alternative in vitro model that enables tracking of the earliest stages of germ cell development. Here, we introduce a defined and efficie...
ORGANISM(S): Homo sapiens 
2015-04-06 | E-GEOD-53498 | biostudies-arrayexpress
TranscriptomicsDirect Reprogramming of Human Neural Stem Cells by OCT4
Induced pluripotent stem (iPS) cells have been generated from mouse and human somatic cells by ectopic expression of the four transcription factors (OCT4, SOX2, c-MYC, KLF4). We previously reported that Oct4 alone is sufficient to directly reprogram adult mouse neural stem cells (NSCs) to iPS cells....
ORGANISM(S): Homo sapiens 
2010-05-20 | E-GEOD-15355 | biostudies-arrayexpress
TranscriptomicsTranscription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice
Maintenance and maturation of primordial germ cells is controlled by complex genetic and epigenetic cascades, and disturbances in this network lead to either infertility or malignant aberration. Transcription factor Tcfap2c / TFAP2C has been described to be essential for primordial germ cell mainten...
ORGANISM(S): Mus musculus 
2014-01-30 | E-GEOD-45941 | biostudies-arrayexpress
TranscriptomicsErythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin
Epigenetic memory in induced pluripotent stem cells (iPSCs), with regards to their somatic cell type of origin, might lead to variations in their differentiation capacities. In this context, iPSCs from human CD34+ hematopoietic stem cells (HSCs) might be more suitable for hematopoietic differentiati...
ORGANISM(S): Homo sapiens 
2015-02-20 | E-GEOD-55109 | biostudies-arrayexpress
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