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TranscriptomicsTranscriptome analysis of diabetic and non diabetic patients affected by post-ischemic heart failure
Increased morbidity and mortality associated with post-ischemic heart failure (HF) in diabetic patients underscore the need for a better understanding of the underlying molecular events. Indeed, effective HF therapy in diabetic patients requires a complex strategy encompassing the development of imp...
ORGANISM(S): Homo sapiens 
2012-03-21 | E-GEOD-26887 | biostudies-arrayexpress
Transcriptomicsautologous pairs of cutaneous melanocyte and melanoma cell cultures
Early-passage (<10 passages) cultures of melanoma cells from metastatic lymph node lesions and normal adult melanocytes explanted in parallel from the adjacent, non-involved skin of 5 patients were compared by cDNA arrays. Differences between normal and neoplastic counterparts were then assessed upo...
ORGANISM(S): Homo sapiens 
2012-09-28 | E-GEOD-38312 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of human Sazary Syndrome tumor and normal samples to define recurrent regions of chromosomal aberrations
This study used tumour and paired normal samples from 28 Sézary Syndrome (SS) patients to define recurrent regions of chromosomal aberrations. Our data identified recurrent losses of 17p13.2-p11.2 and 10p12.1-q26.3 occurring in 71 and 68% of cases respectively; common gains were detected for 17p11.2...
ORGANISM(S): Homo sapiens 
2009-10-10 | E-GEOD-17595 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD3+ T lymphocytes from patients with Sazary Syndrome
This study used tumour and paired normal samples from 28 Sézary Syndrome (SS) patients to define recurrent regions of chromosomal aberrations. Our data identified recurrent losses of 17p13.2-p11.2 and 10p12.1-q26.3 occurring in 71 and 68% of cases respectively; common gains were detected for 17p11.2...
ORGANISM(S): Homo sapiens 
2009-10-10 | E-GEOD-17601 | biostudies-arrayexpress
TranscriptomicssVEGFR-1 signaling through α5β1 integrin
Soluble VEGFR-1 (sVEGFR-1) acts both as a decoy receptor for VEGFs and as an extracellular matrix protein for α5β1 integrin. A sVEGFR-1-derived peptide that interacts with α5β1 integrin promotes angiogenesis. However, canonical signal downstream integrin activation is not induced, resulting into...
ORGANISM(S): Homo sapiens 
2014-01-20 | E-GEOD-32560 | biostudies-arrayexpress
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