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The sarcoglycan complex (SC) is part of a network that links the striated muscle cytoskeleton to the basal lamina across the sarcolemma. The SC coordinates changes in phosphorylation and Ca++-flux during mechanical deformation, and these processes are disrupted with loss-of-function mutations in gam...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD028584 | Pride
We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil-Mut mice express the Svil-encoded N-terminus fused to the bgal-neo gene trap tag and lack the highly conserved archvillin C-terminus; Svil-KO mice lack expression of all known Svil-encoded proteins; ...
ORGANISM(S): Mus musculus 
2026-06-24 | GSE335980 | GEO
Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin-knockout and Supervillin-mutant Mice
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