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ProteomicsArg-C Ultra simplifies histone preparation for LC-MS/MS
Using mammalian histone extract, we demonstrate that Arg-C Ultra facilitates histone preparation for LC-MS/MS. We show the performance of Arg-C Ultra in terms of digestion specificity, number of modified forms identified, and yield of quantitative information compared with standard Arg-C and trypsin...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD059514 | Pride
Histone Arg-c ultra Trimethylacetic anhydride Lc-ms/ms Chemical derivatization 
UnknownSynergistic Arg-C Ultra and Lys-C Digestion for Quantitative Proteomics.
Not available
S-EPMC12338676 | biostudies-literature
UnknownArg-C Ultra Simplifies Histone Preparation for LC-MS/MS.
Not available
S-EPMC12199229 | biostudies-literature
ProteomicsRapid Histone Post-Translational Modification Analysis Using Alternative Proteases and Tandem Mass Tags (RIPUP)
Histone post-translational modifications (PTMs) alter chromatin dynamics and contribute to the regulation of gene expression in health and disease. Mass spectrometry-based analysis is the gold-standard for histone PTM analysis, but it remains constrained by inefficient sample preparation workflows r...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2026-06-20 | PXD073683 | Pride
Post-translational modifications Histones Proteases Lc-ms/ms 
MetabolomicsA Comprehensive and Ultrasensitive Isotope Calibration Method for Soil Amino Compounds Using Orbitrap Mass Spectrometry
Bound amino compounds (amino acid and amino sugar polymers) comprise a significant proportion (~40%) of soil organic nitrogen and therefore represent an essential source of nitrogen for plant and microbial nutrition. The analysis of their content and isotope enrichment still represents a significant...
2025-06-16 | MTBLS12550 | MetaboLights
TranscriptomicsInnate immune pathways in afferent lymph following vaccination with poly(I:C) -containing liposomes
Many modern vaccines use defined adjuvants to stimulate the innate immune system and shape the adaptive immune response. The exact nature of these innate signals and whether immune differentiation can originate within the periphery is not known. In the present study we used an ovine lymphatic cannul...
ORGANISM(S): Ovis aries 
2013-08-01 | E-GEOD-38533 | biostudies-arrayexpress
UnknownRotary mechanism of the prokaryotic V<sub>o</sub> motor driven by proton motive force.
Not available
S-EPMC11579504 | biostudies-literature
Unknown<i>In Vivo</i> Directed Evolution of an Ultra-Fast Rubisco from a Semi-Anaerobic Environment Imparts Oxygen Resistance.
Not available
S-EPMC12247655 | biostudies-literature
TranscriptomicsTranscriptional response of LPS-stimulated monocyte-derived macrophages in the presence or absence of the anti-TNF agonist Etanercept
We measured TNFα activity on the transcriptional level by identifying TNFα-inducible genes in human blood monocyte-derived macrophages (MDM). On the basis that TNFα does not act in isolation, we used bacterial lipopolysaccharide (LPS) as a prototypic model of a stimulus to invoke secretion of a w...
ORGANISM(S): Homo sapiens 
2017-08-04 | E-MTAB-5095 | biostudies-arrayexpress
TranscriptomicsRNA-Seq: Aeroplysinin-1 on gene expression in primary human lung endothelial cells with and without influenza A
Uninfected and influenza (H1N1, x31) conditions were investigated. Three biological replicates were used per group for RNASeq analysis. A non functional derivative of Aeroplysinin-1 was also tested (Ap1) at the same concentration and time point. Samples had an Agilent Bioanalyzer RNA integrity num...
ORGANISM(S): Homo sapiens 
2025-06-14 | E-MTAB-15177 | biostudies-arrayexpress
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