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MetabolomicsLysosomal Acidity and Cathepsin L Activate Eosinophils via ARG1-Mediated Arginine Metabolism in Allergic Airway Inflammation

Eosinophils are the predominant immune cells implicated in the pathogenesis of asthma, highlighting the need for strategies to mitigate their effects. While previous studies have indicated a potential relationship between lysosomes and eosinophils, the precise role of lysosomes in eosinophil acti...

2025-09-15 | MTBLS13001 | MetaboLights
MetabolomicsUntargeted metabolomic profile of reciprocal hemizygotes (oak/win hybrid, genes AUA1, ARG82) (part III)
Not available
ORGANISM(S): Saccharomyces cerevisiae 
ST000871 | MetabolomicsWorkbench
MetabolomicsSupplementing RP-Arg during the gestation and lactation periods of grazing sheep reprograms liver metabolism in offspring lambs by increasing IGF-1 in milk

The nutritional status of ewes during gestation and lactation is a key determinant of lamb growth performance. Supplementing rumen-protected arginine (RP-Arg) during these stages induces maternal metabolic adaptation, thereby maintaining fetal developmental homeostasis. However, the sustained eff...

2025-10-30 | MTBLS13239 | MetaboLights
GenomicsPantoea ananatis strain:31npA-Arg1
Pantoea ananatis strain:31npA-Arg1 Genome sequencing
PRJNA1446712 | ENA
ProteomicsArg1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction
Ischemic/hypoxic injury significantly damages vascular function, detrimentally im-pact-ing patient outcomes. Changes in mitochondrial structure and function are closely associated with ischemia/hypoxia-induced vascular dysfunction. The mecha-nism of this process remains elusive. Using rat models of ...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-06-02 | PXD063156 | Pride
Mtdna Ischemic/hypoxic injury Mitochondria Vascular dysfunction Arg1 
GenomicsArg1+ microglia are critical for shaping cognition in female mice
Arg1+ microglia are critical for shaping cognition in female mice
PRJNA896130 | ENA
TranscriptomicsArginine utilization following mycobacteria infection in macrophages is dependent on autocrine-paracrine signaling
Nitric oxide (NO) produced by macrophages (MØs) is toxic to both host tissues and invading pathogens and its regulation is therefore essential to suppress host cytotoxicity. MØ arginase 1 (Arg1) inhibits NO production by competing with NO synthases for arginine, the common substrate of NO synthases ...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-22935 | biostudies-arrayexpress
GenomicsArg1 expression defines immunosuppressive subsets of immune infiltrating cells in cancer
Arg1 expression defines immunosuppressive subsets of immune infiltrating cells in cancer
PRJNA449347 | ENA
TranscriptomicsArg1 expression defines immunosuppressive subsets of immune infiltrating cells in cancer
Tumor-associated macrophages (TAM) have attracted attention as they can modulate key cancer-related activities, yet TAM represent a heterogenous group of cells that remain incompletely characterized. In growing tumors, TAM are often referred to as M2-like macrophages, which are cells that display im...
ORGANISM(S): Mus musculus 
2018-12-11 | GSE112865 | GEO
UnknownArg1 expression defines immunosuppressive subsets of tumor-associated macrophages.
Not available
S-EPMC6299430 | biostudies-literature
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