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GenomicsHistone arginine demethylation by RDMe1
Histone arginine demethylation by RDMe1
PRJNA514095 | ENA
TranscriptomicsdKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing.
Transcription regulation involves enzyme-mediated changes in chromatin structure. Here, we describe a novel mode of histone crosstalk during gene silencing, in which histone H2A monoubiquitylation is coupled to the removal of histone H3 Lys 36 dimethylation (H3K36me2). This pathway was uncovered thr...
ORGANISM(S): Drosophila melanogaster 
2011-12-13 | E-GEOD-34390 | biostudies-arrayexpress
ProteomicsMina53 demethylates histone 4 arginine 3 asymmetric di-methylation to regulate neural stem/progenitor cell identity
Arginine methylation of histones plays a critical role in regulating gene expression. The writers (methyltransferases) and readers of methylarginine marks are well-known, but the erasers－arginine demethylases－remain mysterious. Here we identify Myc-induced nuclear antigen 53 (Mina53), a jumonji C do...
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD045247 | Pride
Histone methylation Neural stem/progenitor cells Epigenetics Arginine demethylation Mina53 
ProteomicsDeep Protein Arginine Asymmetric Di-Methylation Profiling of Breast Cancer Patient-derived Xenografts
Arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) is a prevalent posttranslational modification that regulates diverse cellular processes. Aberrant expression of type I PRMTs that catalyze asymmetric arginine demethylation (ADMA) is often found in cancer; however, little ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD038203 | Pride
Breast cancer Pdx Adma Lc-ms/ms 
UnknownArginine Demethylation of G3BP1 Promotes Stress Granule Assembly.
Not available
S-EPMC5077203 | biostudies-literature
TranscriptomicsPRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos
Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic reprogramming, which entails comprehensive erasure of DNA methylation. We found that PRMT5, an arginine methyltransferase, translocates from the cytoplasm to the nucleus during this process. Here we show that conditional los...
ORGANISM(S): Mus musculus 
2014-09-09 | E-GEOD-61216 | biostudies-arrayexpress
UnknownJmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships.
Not available
S-EPMC11603075 | biostudies-literature
TranscriptomicsPRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos
Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic reprogramming, which entails comprehensive erasure of DNA methylation. We found that PRMT5, an arginine methyltransferase, translocates from the cytoplasm to the nucleus during this process. Here we show that conditional los...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-60875 | biostudies-arrayexpress
GenomicsHistone arginine demethylation by RDMe1
Histone methylation mainly occurs on lysine and arginine residues. While lysine methylation can be removed by LSD1 and JmjC domain-containing demethylases, the existence of histone arginine demethylases is highly controversial. Here, we performed a high-content cell-based screening of a cDNA library...
ORGANISM(S): Homo sapiens 
2022-01-09 | GSE124890 | GEO
UnknownArginine demethylation is catalysed by a subset of JmjC histone lysine demethylases.
Not available
S-EPMC4931022 | biostudies-literature
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