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ProteomicsARIH2 is a novel Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection
Discovery of novel host-virus interactions leads to a better understanding of mechanisms underlying infection and points to potential therapeutic targets at the interface between virus and host proteins. Recently, global, virus-host interaction networks have been mapped using affinity purification-m...
ORGANISM(S): Homo sapiens (Human) 
2019-04-11 | PXD009012 | Pride
Ap-ms Host-virus interactions Cullin ring e3 ligases Arih2 Cul5 Hiv 
UnknownArih2 gene influences immune response and tissue development in chicken.
Not available
S-EPMC6822486 | biostudies-literature
GenomicsUBE2F inhibits Natural Killer cell tumor immunity by activating the ARIH2-CRL5 complex to degrade interleukin 15 receptors
UBE2F inhibits Natural Killer cell tumor immunity by activating the ARIH2-CRL5 complex to degrade interleukin 15 receptors
PRJNA1259407 | ENA
ProteomicsARIH2 is a novel Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection
Discovery of novel host-virus interactions leads to a better understanding of mechanisms underlying infection and points to potential therapeutic targets at the interface between virus and host proteins. Recently, global, virus-host interaction networks have been mapped using affinity purification-m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-29 | MSV000084855 | MassIVE
TranscriptomicsUBE2F inhibits Natural Killer cell tumor immunity by activating the ARIH2-CRL5 complex to degrade interleukin 15 receptors
Interleukin-15 receptor (IL-15R) agonists induce anti-tumor immunity in pre-clinical models, however, dose-limiting toxicity has hampered their clinical development. An alternative is to target pathways downstream of the IL-15R to access different therapeutic profiles. We performed genome-wide CRISP...
ORGANISM(S): Homo sapiens 
2025-05-13 | GSE296451 | GEO
UnknownArih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation.
Not available
S-EPMC9481925 | biostudies-literature
UnknownCUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation.
Not available
S-EPMC8460447 | biostudies-literature
UnknownARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.
Not available
S-EPMC7153695 | biostudies-literature
UnknownA LisH-domain protein interaction map reveals a Lis1-ARIH2-dynein regulatory axis.
Not available
S-EPMC12648486 | biostudies-literature
UnknownARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.
Not available
S-EPMC9218151 | biostudies-literature
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