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TranscriptomicsGene expression profiling of the AD11 anti-NGF transgenic mouse model of neurodegeneration at 1, 3, 6, 15 months of age
We characterized the gene expression profile of brain regions at different stages of the AlzheimerM-bM-^@M-^Ys like neurodegeneration in the anti-NGF AD11 trangenic mouse model. Total RNA was extracted from hippocampus, cortex and basal forebrain of postnatal day 30 (P30, 1 month), P90 (3 months), P...
ORGANISM(S): Mus musculus 
2015-02-26 | E-GEOD-63617 | biostudies-arrayexpress
TranscriptomicsLamin A/C Is Required For ChAT-Dependent Neuroblastoma Differentiation: a microarray gene expression study
The mouse neuroblastoma N18TG2 clone is unable to differentiate and defective for the enzymes of the biosynthesis of neurotransmitters. The forced expression of choline acetyltransferase (ChAT) in these cells results in the synthesis and release of acetylcholine (Ach) and hence in the expression of ...
ORGANISM(S): Mus musculus 
2017-04-18 | E-GEOD-73591 | biostudies-arrayexpress
TranscriptomicsTargeting MDM4/MDM2 binding interface for reactivation of p53 in cancer therapy
The aim of this experiment has been to investigate the transcriptional profile of HCT116 cells treated with Peptide-3 (Pep3) compared to untreated (NT), treated with solvent (DMSO) or with a mutated peptide (Pep3M) cells. Peptide-3 is a dodecapeptide able to interact with MDM2 at the levels of the i...
ORGANISM(S): Homo sapiens 
2017-04-18 | E-GEOD-62855 | biostudies-arrayexpress
TranscriptomicsCaco-2 cells: 21-days differentiated cells maintained with the low density protocol (LD cells) vs 21-days differentiated cells maintained with the high density protocol (HD cells)
Transcriptional profile of 21-days differentiated LD Caco-2 cells compared to 21-days differentiated HD Caco-2 cells. Goal was to find some differences in the genome profile of the LD and HD Caco-2 cells that could be addressed to the different protocols used for the line maintenance. Two-condition ...
ORGANISM(S): Homo sapiens 
2011-04-25 | E-GEOD-21518 | biostudies-arrayexpress
TranscriptomicsCaco-2 cells: cycling vs 21-days differentiated cells
Transcriptional profile of 21-days differentiated Caco-2 cells compared to Caco-2 cycling cells. Goal was to demonstrate the ability of Caco-2 cells to express most of the markers typical of differentiated enterocytes. A novel protocol of line maintenance was used. Two-condition experiment: cycling ...
ORGANISM(S): Homo sapiens 
2011-04-25 | E-GEOD-21519 | biostudies-arrayexpress
TranscriptomicsNGF and proNGF activate functionally distinct mRNAs in PC12 cells: an early gene expression profiling
The biological activities of NGF and of its precursor proNGF are quite distinct, due to different receptor binding profiles, but nothing is known about how proNGF regulates gene expression. We performed experiments to address this question, by verifying whether a proNGF specific transcriptional sign...
ORGANISM(S): Rattus norvegicus 
2012-01-09 | E-GEOD-26528 | biostudies-arrayexpress
TranscriptomicsLamin A/C is required for SHSY5Y neuroblastoma cell differentiation and its expression is linked to a less malignant phenotype.
The main scientific objective of the project was to investigate whether Lamin A/C could be involved in neuroblastoma differentiation. Moreover, taking into account the significance of differentiation stage in the neuroblastoma tumor progression we have also studied a possible role of Lamin A/C in th...
ORGANISM(S): Homo sapiens 
2013-07-11 | E-GEOD-30677 | biostudies-arrayexpress
TranscriptomicsThe TIMP3/Apelin axis Regulates Atherosclerosis and Heart Metabolism leading to increased mortality in ApoE null Mice
The role of TIMP3 in the context of cardiovascular remodeling is relatively unexplored when considering classical risk factors such as hypercholesterolemia, diabetes and hypertension. To learn more the role of TIMP3 in the progression of cardiovascular disease we combined genetics, metabolomics and ...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-53548 | biostudies-arrayexpress
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