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UnknownLeft Bundle Branch Pacing: A New Alternative to Resynchronization Therapy in the 2020 Pacing Armamentarium.
His bundle pacing was developed while seeking a physiological alternative to biventricular cardiac resynchronization therapy. However, His bundle pacing may not be adequate in all patients. In this scenario, left bundle branch pacing has arisen as a new cardiac resynchronization therapy modality to ...
S-EPMC8299856 | biostudies-literature
ProteomicsBreaking the mucin barrier: a new affinity chromatography-mass spectrometry approach to unveil potential cell markers and pathways altered in Pseudomyxoma peritonei
Pseudomyxoma peritonei (PMP) is a rare, malignant tumour with unknown underlying molecular mechanisms characterised by a progressive accumulation of mucin and secreting tumour cells within the abdomen and pelvis. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HI...
ORGANISM(S): Homo sapiens (Human) Trypanosoma cruzi cruzi 
2024-06-22 | PXD037364 | Pride
Swath Differential expresion Pseudomyxoma peritonei Mucin 
UnknownDysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug.

Background

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, requiring novel treatments to target both cancer cells and cancer stem cells (CSCs). Altered splicing is emerging as both a novel cancer hallmark and an attractive therapeutic target. The core splicing factor SF3B1...
S-EPMC8638119 | biostudies-literature
UnknownCleaning products and short-term respiratory effects among female cleaners with asthma.

Objective

We evaluated the short-term effects of exposure to cleaning products on lung function and respiratory symptoms among professional cleaning women.

Methods

Twenty-one women with current asthma and employed as professional cleaners participated in a 15-day panel study. During 3...
S-EPMC8856568 | biostudies-literature
UnknownCIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative.
CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedica...
S-EPMC9305285 | biostudies-literature
UnknownTransferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations.
A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal flu...
S-EPMC12283339 | biostudies-literature
UnknownNew insights into the genetic etiology of Alzheimer's disease and related dementias.
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'pro...
S-EPMC9005347 | biostudies-literature
UnknownCommon variants in Alzheimer's disease and risk stratification by polygenic risk scores.
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all avai...
S-EPMC8184987 | biostudies-literature
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