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MetabolomicsMicrobial -Enzymatic Mucin Metabolic Relay Suppresses Tumor Progression in Apcmin/+ mice

Compelling evidence established the gut microbiota as a pivotal regulator of colorectal cancer (CRC) progression, although stage-specific mechanisms remain unclear. Our investigation in Apcmin/+ mice mapped tumor growth and microbial shifts across early, intermediate, and advanced stage...

2025-07-20 | MTBLS12754 | MetaboLights
MetabolomicsMicrobial -Enzymatic Mucin Metabolic Relay Suppresses Tumor Progression in Apcmin/+ mice

Compelling evidence established the gut microbiota as a pivotal regulator of colorectal cancer (CRC) progression, although stage-specific mechanisms remain unclear. Our investigation in Apcmin/+ mice mapped tumor growth and microbial shifts across early, intermediate, and advanced stage...

2025-07-24 | MTBLS12770 | MetaboLights
TranscriptomicsTranscriptional profiling of C. albicans in the presence of mucin versus absence of mucin
Candida albicans is the most prevalent fungal pathogen of humans, causing a variety of diseases ranging from superficial mucosal infections to deep-seated systemic infections. Mucus, the gel that coats all wet epithelial surfaces, accommodates Candida albicans as part of the regular microbiome where...
ORGANISM(S): Candida albicans 
2014-03-11 | E-GEOD-55766 | biostudies-arrayexpress
TranscriptomicsCampylobacter jejuni Utilization of Mucin
While growing in the human intestine, C. jejuni grows within the mucus layer. The largest constituents of this layer are the large mucin glycoproteins. A transcriptomic profile of C. jejuni NCTC11168 growing in a mucin-containing minimal medium seeks to describe the effect of the presence of mucin...
ORGANISM(S): Campylobacter jejuni 
2011-04-01 | E-GEOD-28295 | biostudies-arrayexpress
TranscriptomicsCross-feeding by Bifidobacterium breve UCC2003 during Bifidobacterium bifidum PRL2010 growth on a mucin-based medium.
Bifidobacteria constitute commensal bacteria that commonly inhabit the mammalian gastro intestinal tract. The gut commensal Bifidobacterium breve UCC2003 was previously shown to utilise a variety of plant/diet-derived carbohydrates, including cellodextrin, starch and galactan. In the current study, ...
ORGANISM(S): Bifidobacterium breve UCC2003 
2014-12-17 | E-GEOD-59013 | biostudies-arrayexpress
ProteomicsMucin-binding proteins of E. coli membrane
Proteins from E. coli outer membrane were extracted with carbonate method, separated in 2D-PAGE and transferred onto nitrocellulose membrane. After incubation with flourescent-labelled mucin, mucin-binding protein spots were cut out, subjected to trypsinolysis and identified by protein analysis wit...
ORGANISM(S): Escherichia coli 
2019-12-16 | PXD010472 | Pride
Escherichia coli Hplc-ms-ms Mucin binding Membrane 
TranscriptomicsA GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes.
GNAS, a gene encoding G-protein stimulating alpha subunit, is frequently mutated in intraductal papillary mucinous neoplasms (IPMNs), which is an indolent and slow-growing pancreatic neoplasm that secretes abundant mucin. GNAS mutation is not observed in conventional ductal adenocarcinomas of the pa...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-53350 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse intestine in ENU mutagenesis mouse strains with missense mutations in Muc2 mucin and ER stress
Background; MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. MUC2 homo-oligomerizes intracellularly into large secreted polymers which give mucus its viscous properties. The inflammatory bowel disease (IBD) ulcerative colitis is characterized by...
ORGANISM(S): Mus musculus 
2008-04-06 | E-GEOD-9913 | biostudies-arrayexpress
ProteomicsHuman plasma proteins detected by HPLC-MS/MS after blood incubation with E. coli treated/not treated with mucin
Whole human blood incubated with E. coli isolate with or without bound mucin. Plasma was obtained and the effect of mucin bound to E. coli on plasma proteins content was analysed by HPLC-MS-MS.
ORGANISM(S): Homo sapiens (Human) 
2019-12-16 | PXD010496 | Pride
Plasma Mucin E. coli 
ProteomicsMucin drives human gut microbial ecological interactions in an in vitro synthetic community
In this study, we created a synthetic mucin-degrading microbial community to specifically study mucin-driven ecological interactions in vitro. The synthetic community consisted of primary mucin degraders and cross-feeders. We tracked community composition and dynamics and the mucin-degrading enzymes...
ORGANISM(S): Desulfovibrio piger ATCC 29098 Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) Anaerostipes caccae DSM 14662 Faecalibacterium prausnitzii A2-165 Roseburia intestinalis L1-82 Methanobrevibacter smithii DSM 11975 Phocaeicola vulgatus ATCC 8482 Ruminococcus gnavus ATCC 29149 Anaerobutyricum hallii DSM 3353 Blautia hydrogenotrophica DSM 10507 Akkermansia muciniphila ATCC BAA-835 Bacteroides caccae ATCC 43185 Agathobacter rectalis ATCC 33656 Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) [Ruminococcus] torques ATCC 27756 
2025-03-12 | PXD051481 | Pride
Gut microbiota Mucin Ecological interactions Cross-feeding Synthetic community 
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