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ProteomicsMetabolic dependencies in MYCN-driven neuroblastoma
Here we sought metabolic alterations specifically associated with amplified MYCN as nodes to indirectly target the MYCN oncogene. Liquid chromatography-mass spectrometry-based proteomics identified 7 proteins consistently correlated with MYCN in proteomes from 49 neuroblastoma biopsies and 13 cell l...
ORGANISM(S): Homo sapiens (Human) 
2020-12-11 | PXD018300 | Pride
Mycn Cancer cell metabolism De novo serine synthesis pathway One carbon metabolism Therapy resistance Cell death 
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