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TranscriptomicsMYCN overexpression in SH-SY5Y/6TR(EU)/pTrex-Dest-30/MYCN cell line
MYCN overexpression in the doxycline MYCN inducible cell line SH-SY5Y/6TR(EU)/pTrex-Dest-30/MYCN (SY5Y-MYCN) using the dynamic transcriptome analysis (DTA) protocol. Samples at different time-points after MYCN over-expression and uninduced controls (0h) were sequenced in duplicates. The experimental...
ORGANISM(S): Homo sapiens 
2014-12-30 | E-MTAB-2691 | biostudies-arrayexpress
GenomicsGenome-wide mapping of MYCN binding in neuroblastoma cells
To identify the MYCN transcription factor binding sites across the genome, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) using anti-MYCN and anti-IgG antibodies on a MYCN-amplified NB cell line, SK-N-BE(2)-C. Identification of MYCN binding in neuroblastoma cells.
ORGANISM(S): Homo sapiens 
2016-05-16 | E-GEOD-72640 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human neuroblastoma cells shows MYCN-regulated MicroRNAs repress estrogen receptor-alpha expression
Effect of MYCN expression on microRNA transcriptome in human neuroblastoma.
ORGANISM(S): Homo sapiens 
2009-04-01 | E-MEXP-2006 | biostudies-arrayexpress
TranscriptomicsEffects of MYCN knockdwon on miRNA expression in neuroblastoma cells
Global miRNAs expression profilling of SK-N-BE(2)-C cells after dsRNA-mediated knockdown of MYCN To identify MYCN-associated miRNAs, we carried out a small RNA-seq on MYCN knockdown in SK-N-BE(2)-C cells to profile the miRNA expression.
ORGANISM(S): Homo sapiens 
2016-05-16 | E-GEOD-72721 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cell lines reveals Dickkopf-1 is down-regulated by MYCN and inhibits neuroblastoma cell proliferation
Neuroblastomas are tumors of the developing peripheral sympathetic nervous system, which originates from the neural crest. Twenty percent of neuroblastomas show amplification of the MYCN oncogene, which correlates with poor prognosis. The MYCN transcription factor can activate and repress gene expre...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8066 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblastoma cell line SHEP expressing a MYNC trasngene against controls which have the transgene silenced by tetracycline
MYCN is an oncogene amplified in approximately 20% of all neuroblastomas and 50% of high risk neuroblastoma. It is a transcription factor regulating the expression of genes involved in proliferation and apoptosis.We would like to identify genes potentially regulated by MYCN in a conditional MYCN exp...
ORGANISM(S): Homo sapiens 
2010-02-18 | E-MEXP-2340 | biostudies-arrayexpress
TranscriptomicsInactivation of CDK2 is synthetic lethal to MYCN-overexpressing cancer cells
Two genes have a synthetic lethal relationship when silencing or inhibition of one gene is only lethal in the context of a mutation or activation of the second gene. This situation offers an attractive therapeutic strategy, as inhibition of such a gene will only trigger cell death in tumor cells wit...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-16480 | biostudies-arrayexpress
ProteomicsThe MYCN oncoprotein is an RNA-binding protein that promotes nascent RNA turnover via the NEXT targeting complex of the nuclear exosome
The MYCN oncoprotein forms a DNA-binding heterodimer with its partner protein MAX. MYCN-driven tumor cells depend on the nuclear exosome, a 3`-5` RNA exonuclease complex, to progress through S phase. Here we show that MYCN forms stable high molecular weight complexes with the nuclear exosome and add...
ORGANISM(S): Homo sapiens (Human) 
2024-07-18 | PXD044446 | Pride
Neuroblastoma Exosome Mycn Next Mxd Zcchc8 Myc Intron Max Mnt Eclip 
TranscriptomicsGene expression profiling of MYCN-driven neuroblastoma tumor development in the TH-MYCN mouse model.
Neuroblastoma is an embryonic tumor arising from immature sympathetic nervous system progenitor cells. MYCN and ALK are driver oncogenes both of which are specifically expressed during early neurogenesis. This is in line with the assumption that neuroblastoma arises through disruption of normal deve...
ORGANISM(S): Mus musculus 
2016-02-28 | E-MTAB-3247 | biostudies-arrayexpress
TranscriptomicsTargeting MYCN in Neuroblastoma by BET Bromodomain Inhibition
Bromodomain inhibition comprises a promising therapeutic strategy in cancer, particularly for hematologic malignancies. To date, however, genomic biomarkers to direct clinical translation have been lacking. We conducted a cell-based screen of genetically-defined cancer cell lines using a prototypica...
ORGANISM(S): Homo sapiens 
2013-02-25 | E-GEOD-43392 | biostudies-arrayexpress
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