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MetabolomicsHigh-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program
Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality, but the molecular underpinnings of this association are poorly understood. Here, we demonstrate in a murine prostate cancer m...
2019-08-22 | MTBLS135 | MetaboLights
MetabolomicsCXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury
Kidney injury is a common complication of severe disease. Here, we report that injuries of the zebrafish embryonal kidney are rapidly repaired by a migratory response in 2-, but not in 1-day-old embryos. Gene expression profiles between these two developmental stages identify cxcl12a and myca as can...
2018-10-11 | MTBLS723 | MetaboLights
MetabolomicsObesogenic high-fat diet and MYC cooperate to promote lactate accumulation and tumor microenvironment remodeling in prostate cancer (Murine serum assays)

Cancer cells exhibit metabolic plasticity to meet oncogene-driven dependencies while coping with nutrient availability. A better understanding of how systemic metabolism impacts the accumulation of metabolites that reprogram the tumor microenvironment and drive cancer could facilitate development...

2024-04-10 | MTBLS3316 | MetaboLights
MetabolomicsObesogenic high-fat diet and MYC cooperate to promote lactate accumulation and tumor microenvironment remodeling in prostate cancer (Murine prostate assays)

Cancer cells exhibit metabolic plasticity to meet oncogene-driven dependencies while coping with nutrient availability. A better understanding of how systemic metabolism impacts the accumulation of metabolites that reprogram the tumor microenvironment and drive cancer could facilitate development...

2024-04-10 | MTBLS3317 | MetaboLights
MetabolomicsCancer-cell-secreted exosomal miR-105 promotes tumour growth through the Myc-dependent metabolic reprogramming of stromal cells
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and to buffer the negative effects of environmental changes. Extracellular miRNAs have been recently implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-canc...
2018-07-10 | MTBLS626 | MetaboLights
TranscriptomicsDeep sequencing of MYC DNA-binding sites in Burkitt's lymphoma
Background: MYC is a transcription factor encoded by the c-MYC gene (thereafter termed MYC). MYC is key transcription factor involved in many central cellular processes including ribosomal biogenesis. MYC is overexpressed in the majority of human tumours including aggressive B-cell lymphoma especial...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-30726 | biostudies-arrayexpress
GenomicsTelomerase subunit TERT regulates MYC stability independent of its role on telomeres (ChIP-Seq)
Constitutively active MYC and reactivated telomerase often co-exist in cancers. While the reactivation of telomerase is thought to be essential for replicative immortality, MYC, in conjunction with co-factors, confers several growth advantages to cancer cells. However, it is unclear which co-factors...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-60223 | biostudies-arrayexpress
ProteomicsMYC as a Key Regulator of Protein Synthesis: Characterization of Downstream Targets in Multiple Myeloma
Multiple myeloma (MM) is a malignant plasma cell disorder and frequently characterized by the 16 dysregulation of the MYC oncogene, which is associated with poor prognosis and disease progression. While MYC's involvement in transcriptional regulation is well-established, the functional role of MYC t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-15 | MSV000092169 | MassIVE
ProteomicsLarge bidirectional remodeling of the Myc-induced cell surface proteome in B-cells and prostate cells creates new opportunities for immunotherapy
To identify how MYC overexpression remodels the cell surface proteome in a cell autologous fashion and in different cell types, we investigated the impact of MYC overexpression on ~800 surface proteins in three isogenic model cell lines either of B-cell or prostate cell origin that were engineered t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-08-07 | MSV000085930 | MassIVE
MetabolomicsMeasurement of free amino acid (AA) in response to MYC
Not available
ORGANISM(S): Homo sapiens 
ST000249 | MetabolomicsWorkbench
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