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TranscriptomicsGene expression changes induced by Benzo[a]pyrene (BaP) in human breast carcinoma cell line MCF-7 in different phases of the cell cycle
Benzo[a]pyrene (BaP) is a widespread environmental genotoxic carcinogen that damages DNA by forming adducts. This damage with along the activation of the aryl hydrocarbon receptor (AHR) induces complex transcriptional responses in cells. To investigate whether human cells are more susceptible to BaP...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-26917 | biostudies-arrayexpress
TranscriptomicsPulmonary gene expression in MutaTMMouse orally gavaged with three doses of benzo(a)pyrene and vehicle control
In this study, we investigate mRNA profiles in lung of mice exposed to benzo(a)pyrene. Male mice were exposed to three doses (25, 50, and 75 mg/kg/day BaP) for 28 days and profiles were examined three days post-exposure. Our analyses reveal that BaP causes pulmonary specific cellular transformation ...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-35718 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by the human aristolochic acid I in renal and hepatic tissue of mice
Aristolochic acid (AA) is the causative agent of urothelial tumours associated with aristolochic acid nephropathy and is also implicated in the development of Balkan endemic nephropathy-associated urothelial tumours. These tumours contain AA-characteristic TP53 mutations. We examined gene expression...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-18246 | biostudies-arrayexpress
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