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ProteomicsARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans
ARMC5 is an armadillo domain (ARM)-containing protein. We found that Armc5 KO mice had an increased incidence of neural tube defects (NTDs). ARMC5 is the substrate recognition component of a ubiquitin ligase that targets POLR2A, the largest subunit of RNA polymerase II (Pol II). Surprisingly, the ab...
ORGANISM(S): Homo sapiens (Human) 
2023-12-06 | PXD047572 | Pride
Myelomeningocele Armc5 Pol ii pool size Folh1 12 subunits of pol ii Polr2a-specific e3 Ubiquitin ligase Cullin 3 Neural tube defects 
ProteomicsARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans
ARMC5 is an armadillo domain (ARM)-containing protein. We found that Armc5 KO mice had an increased incidence of neural tube defects (NTDs). ARMC5 is the substrate recognition component of a ubiquitin ligase that targets POLR2A, the largest subunit of RNA polymerase II (Pol II). Surprisingly, the ab...
ORGANISM(S): Homo sapiens (Human) 
2023-12-06 | PXD047533 | Pride
Myelomeningocele Armc5 Pol ii pool size Folh1 12 subunits of pol ii Polr2a-specific e3 Ubiquitin ligase Cullin 3 Neural tube defects 
GenomicsRPB1 ChIP-Seq of NSC from Wild Type (WT) and Armc5 knockout mice
RPB1 ChIP-Seq of NSC from Wild Type (WT) and Armc5 knockout mice
PRJNA717040 | ENA
UnknownPrimary Aldosteronism and ARMC5 Variants.
Not available
S-EPMC4454793 | biostudies-literature
UnknownAnalysis of ARMC5 expression in human tissues.
Not available
S-EPMC5235969 | biostudies-literature
GenomicsSPT5 regulates RNA polymerase II stability via Cullin 3–ARMC5 recognition [RNA-Seq]
SPT5 regulates RNA polymerase II stability via Cullin 3–ARMC5 recognition [RNA-Seq]
PRJNA1162056 | ENA
GenomicsSPT5 regulates RNA polymerase II stability via Cullin 3–ARMC5 recognition [ChIP-seq]
SPT5 regulates RNA polymerase II stability via Cullin 3–ARMC5 recognition [ChIP-seq]
PRJNA1162054 | ENA
GenomicsRNA-Seq of neural stem cells from Wild Type (WT) and Armc5 knockout mice
RNA-Seq of neural stem cells from Wild Type (WT) and Armc5 knockout mice
PRJNA716311 | ENA
UnknownAge-dependent effects of Armc5 haploinsufficiency on adrenocortical function.
Not available
S-EPMC6074838 | biostudies-literature
UnknownARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans.
Not available
S-EPMC10789052 | biostudies-literature
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