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ProteomicsStage-specific proteomes from Onchocerca ochengi, sister species of the human river blindness parasite, uncovers adaptations to a nodular lifestyle
In spite of 40 years of control efforts, onchocerciasis (river blindness) remains one of the most important neglected tropical diseases, with 17 million people affected. The aetiological agent, Onchocerca volvulus, is a filarial nematode with a complex lifecycle involving several distinct stages in ...
ORGANISM(S): Onchocerca ochengi (Filarial nematode worm) 
2016-05-31 | PXD002889 | Pride
Lc-msms River blindness Onchocerca ochengi 
UnknownDiscovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441.
Not available
S-EPMC11358143 | biostudies-literature
ProteomicsProteomic analysis of the global response of an arthropod Wolbachia symbiont to doxycycline-induced stress
The bacterium Wolbachia (order Rickettsiales), representing perhaps the most abundant vertically transmitted microbe worldwide, infects arthropods and filarial nematodes. In arthropods, Wolbachia can induce reproductive alterations and interfere with the transmission of several arthropod-borne patho...
ORGANISM(S): Wolbachia sp. wMelPop 
2013-10-21 | PXD000345 | Pride
Tetracyclines/tolerance/wolbachia/lc-msms 
ProteomicsUnique insights in cervicovaginal Lactobacillus iners and L. crispatus proteome changes associated with microbiome dysbiosis
Cervicovaginal lavage (CVL)supernatants were heat inactivated for 30 minutes at 56°C before further processing. Total protein concentrations were determined using the Pierce Coomassie Plus (Bradford) Protein Assay (Thermo Scientific, Rockford, IL, USA). Sample protein content and volume were normali...
ORGANISM(S): Homo sapiens (Human) Lactobacillus iners Lactobacillus crispatus 
2016-03-15 | PXD003176 | Pride
Label free proteomics Cervicovaginal microbiome dysbiosis 
UnknownHydroxymethylation is uniquely distributed within term placenta, and is associated with gene expression.
Not available
S-EPMC4970608 | biostudies-literature
UnknownStructure of a monomeric photosystem II core complex from a cyanobacterium acclimated to far-red light reveals the functions of chlorophylls d and f.
Not available
S-EPMC8689208 | biostudies-literature
UnknownDevelopment of a cloud-based application for the Fracture Liaison Service model of care.
Not available
S-EPMC4740567 | biostudies-literature
UnknownA peripherally restricted P2Y12 receptor antagonist altered rat tumor incidences with no human relevance: Mode of action consistent with dopamine agonism.
Not available
S-EPMC5598522 | biostudies-literature
ProteomicsDissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms
Here, we report the first complete genomes of three cultivable treponeme species from bovine digital dermatitis (DD) skin lesions, two comparative human treponemes and a bovine gastrointestinal (GI) isolate. Key genomic differences between bovine and human treponemes implicate microbial mechanisms t...
ORGANISM(S): Treponema sp. T19 Treponema pedis Treponema ruminis Treponema phagedenis Treponema medium Treponema sp. T320A 
2021-03-16 | PXD022419 | Pride
Bovine digital dermatitis Treponemes Shotgun lc msms 
UnknownCardiovascular Disease in Survivors of Childhood Cancer: Insights Into Epidemiology, Pathophysiology, and Prevention.
Not available
S-EPMC6804893 | biostudies-literature
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