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TranscriptomicsTranscription profiling of gonads from E14.5 megalin+/+ and megalin-/- embryos
Presently, genes regulated by steroid hormones during induced regression of the CSL (cranial suspensory ligament) are unknown. To identify such genes and to evaluate their expression levels in megalin-deficient mice, we performed global gene expression profiling on gonads from E14.5 megalin+/+ and m...
ORGANISM(S): Mus musculus 
2005-06-30 | E-MEXP-352 | biostudies-arrayexpress
TranscriptomicsThe transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation
T-bet is critical for cytotoxic T lymphocyte (CTL) differentiation, but it is unclear how it operates in a graded manner in the formation of both terminal effector and memory precursor cells during infection. We find that at high concentrations T-bet induced expression of Zeb2 mRNA, which then trigg...
ORGANISM(S): Mus musculus 
2015-09-15 | E-GEOD-72408 | biostudies-arrayexpress
UnknownAn ultrasound-based simulation to improve clinical competency in evaluation of first-trimester bleeding in undergraduate medical education.
Not available
S-EPMC12065712 | biostudies-literature
ProteomicsMultivalent lipid targeting by the calcium-independent C2A domain of Slp-4/granuphilin
Synaptotagmin-like protein 4 (Slp-4), also known as granuphilin, is a Rab effector responsible for docking insulin secretory vesicles to the plasma membrane prior to exocytosis. Slp-4 binds vesicular Rab proteins via an N-terminal Slp homology (SHD) domain, interacts with plasma membrane SNARE comp...
ORGANISM(S): Homo sapiens (Human) 
2020-12-08 | PXD021393 | Pride
Granuphilin Intact protein Phosphogluconate Lcms 
UnknownThe DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia.
Not available
S-EPMC6265654 | biostudies-literature
UnknownMaternal weight affects placental DNA methylation of genes involved in metabolic pathways in the common marmoset monkey (Callithrix jacchus).
Not available
S-EPMC7154656 | biostudies-literature
UnknownFXR deletion in hepatocytes does not affect the severity of alcoholic liver disease in mice.
Not available
S-EPMC6168334 | biostudies-literature
TranscriptomicsRNA expression analysis upon JMJD1C depletion
The AML1-ETO fusion protein, a transcription factor generated by the t(8;21) translocation in acute myeloid leukaemia (AML), dictates a leukemic program by increasing self-renewal and inhibiting differentiation. Here we demonstrate that the histone demethylase JMJD1C functions as a co-activator for...
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-63485 | biostudies-arrayexpress
GenomicsGenome-wide map of JMJD1C binding in Kasumi-1 cells [ChIP-seq]
The AML1-ETO fusion protein, a transcription factor generated by the t(8;21) translocation in acute myeloid leukaemia (AML), dictates a leukemic program by increasing self-renewal and inhibiting differentiation. Here we demonstrate that the histone demethylase JMJD1C functions as a co-activator for...
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-63484 | biostudies-arrayexpress
ModelsPerrett2014 - GnRH pulse, ERK activity
No description
2016-02-10 | MODEL1509050002 | BioModels
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