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ProteomicsMultivalent lipid targeting by the calcium-independent C2A domain of Slp-4/granuphilin
Synaptotagmin-like protein 4 (Slp-4), also known as granuphilin, is a Rab effector responsible for docking insulin secretory vesicles to the plasma membrane prior to exocytosis. Slp-4 binds vesicular Rab proteins via an N-terminal Slp homology (SHD) domain, interacts with plasma membrane SNARE comp...
ORGANISM(S): Homo sapiens (Human) 
2020-12-08 | PXD021393 | Pride
Granuphilin Intact protein Phosphogluconate Lcms 
UnknownThe Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules.
Not available
S-EPMC135591 | biostudies-literature
UnknownThe C2 domains of granuphilin are high-affinity sensors for plasma membrane lipids.
Not available
S-EPMC4085138 | biostudies-literature
UnknownMunc13b stimulus-dependently accumulates on granuphilin-mediated, docked granules prior to fusion.
Not available
S-EPMC10511056 | biostudies-literature
UnknownPancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis.
Not available
S-EPMC117613 | biostudies-literature
UnknownMultivalent lipid targeting by the calcium-independent C2A domain of synaptotagmin-like protein 4/granuphilin.
Not available
S-EPMC7857503 | biostudies-literature
UnknownThe Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane.
Not available
S-EPMC3564536 | biostudies-literature
UnknownThe Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame.
Not available
S-EPMC263820 | biostudies-literature
UnknownNeurexin-1α contributes to insulin-containing secretory granule docking.
Not available
S-EPMC3307300 | biostudies-literature
UnknownFunctional hierarchy among different Rab27 effectors involved in secretory granule exocytosis.
Not available
S-EPMC9988257 | biostudies-literature
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