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TranscriptomicsDysregulated Expression of Lipid Storage and Membrane Dynamics Factors in Tia1 Knock-Out Mouse Nervous Tissue
During cell stress, the transcription and translation of immediate early genes are prioritized, while most other mRNAs are stored away in stress granules or degraded in P-bodies. TIA-1 is an mRNA binding protein that needs to translocate from the nucleus to seed the formation of stress granules in t...
ORGANISM(S): Mus musculus 
2014-10-06 | E-GEOD-54418 | biostudies-arrayexpress
TranscriptomicsPotentiation of neurotoxicity in double mutant mice with Pink1 ablation and A53T-SNCA overexpression
As the second most frequent neurodegenerative disorder of old age, ParkinsonM-bM-^@M-^Ys disease (PD) can result from autosomal dominant causes like increased alpha-synuclein (SNCA) dosage, or from autosomal recessive causes like PINK1 loss-of-function. Interactions between these triggers and their ...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-60414 | biostudies-arrayexpress
UnknownAssociation of caregiver attitudes with adolescent HPV vaccination in 13 southern US states.
Not available
S-EPMC9250032 | biostudies-literature
TranscriptomicsParkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
Parkinson's disease (PD) is an adult-onset movement disorder of largely unknown etiology. We have previously shown that loss-of-function mutations of the mitochondrial protein kinase PINK1 (PTEN induced putative kinase 1) cause the recessive PARK6 variant of PD. Now we generated a PINK1 deficient mo...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-60413 | biostudies-arrayexpress
TranscriptomicsAlpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization
Alpha-synuclein is an abundant protein implicated in synaptic function and plasticity, but the molecular mechanism of its action is not understood. Missense mutations and gene duplication/triplication events result in Parkinson's disease, a neurodegenerative disorder of old age with impaired movemen...
ORGANISM(S): Mus musculus 
2010-07-21 | E-GEOD-19534 | biostudies-arrayexpress
UnknownSelf-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells.
Not available
S-EPMC6205408 | biostudies-literature
UnknownA Pediatric Interprofessional Cardiac Intensive Care Unit Intervention: CICU Teams and Loved Ones Communicating (CICU TALC) is Feasible, Acceptable, and Improves Clinician Communication Behaviors in Family Meetings.
Not available
S-EPMC11531608 | biostudies-literature
GenomicsPAPD5, a noncanonical poly(A) polymerase with an unusual RNA-binding motif [PAR-CLIP]
PAPD5 is one of the seven members of non-canonical poly(A) polymerases in human cells. There are previous reports about polyadenylation dependent degradation of pre-ribosomal RNAs and uridylation dependent degradation of histone mRNAs in vivo. In this study, we observed polyadenylation but not polyu...
ORGANISM(S): Homo sapiens 
2012-04-02 | E-GEOD-36987 | biostudies-arrayexpress
UnknownFerric carboxymaltose versus standard-of-care oral iron to treat second-trimester anaemia in Malawian pregnant women: a randomised controlled trial.
Not available
S-EPMC10193370 | biostudies-literature
UnknownHearing Loss and Irritability Reporting Without Vestibular Differences in Explosive Breaching Professionals.
Not available
S-EPMC7772348 | biostudies-literature
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