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UnknownA Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome.
Not available
S-EPMC3153307 | biostudies-literature
Unknownp190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation.
Not available
S-EPMC5309857 | biostudies-literature
TranscriptomicsGene expression programs of histologically distinct stages of prostate carcinogenesis in Nkx3.1; Pten mutant mice
Key histological and growth progression characteristics of human prostate cancer are phenocopied in mouse models that have been subjected to androgen level depletion and engineered for hemizygosity of candidate prostate cancer tumor suppressor genes Nkx3.1 and Pten. To characterize their relative tr...
ORGANISM(S): Mus musculus 
2009-10-31 | E-GEOD-15943 | biostudies-arrayexpress
TranscriptomicsSubtype-specific peripheral blood gene expression profiles in recent onset JIA
Objective: A multi-center study of recent onset juvenile idiopathic arthritis (JIA) subjects prior to treatment with DMARDS or biologics was undertaken to identify peripheral blood gene expression differences between JIA subclasses and controls. Methods: PBMC from 59 healthy children and 136 JIA ...
ORGANISM(S): Homo sapiens 
2009-06-30 | E-GEOD-13501 | biostudies-arrayexpress
UnknownShared gene expression profiles in developing heart valves and osteoblast progenitor cells.
Not available
S-EPMC2536828 | biostudies-literature
TranscriptomicsGenome-wide CRISPR-Cas9 screens reveal loss of redundancy between PKMYT1 and WEE1 in Glioblastoma stem-like cells
To identify new therapeutic targets for Glioblastoma (GBM), we performed genome-wide CRISPR-Cas9 "knockout" (KO) screens in patient-derived GBM stem-like cells (GSCs) and human neural stem/progenitors (NSCs), non-neoplastic stem cell controls, for genes required for their in vitro growth. ...
ORGANISM(S): Homo sapiens 
2016-02-15 | E-GEOD-70038 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mononuclear cells from juvenile arthritis and spondyloarthropathy patients
Biotinylated cRNA was synthesized from total RNA (Enzo; Farmingdale, NY) and processed according to the Affymetrix GeneChip Expression Analysis Technical Manual (Affymetrix; Santa Clara, CA). 57 samples: 5 pauciarticular PBMC, 15 polyarticular PBMC, 11 control PMBC, 6 JSpA PBMC, 5 pauciarticular SF...
ORGANISM(S): Homo sapiens 
2007-08-14 | E-GEOD-1402 | biostudies-arrayexpress
UnknownAtlas of gene expression in the developing kidney at microanatomic resolution.
Not available
S-EPMC2653061 | biostudies-literature
UnknownChromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1.
Not available
S-EPMC6101278 | biostudies-literature
TranscriptomicsmTOR inhibitors synergistically induce regression, reversal of gene expression and autophagy in hepatocellular carcinoma
The mTOR-allosteric inhibitor, RAD001, in combination with a PI3K/mTOR ATP-site competitive inhibitor, BEZ235, causes gene reprogramming, autophagy and tumor regression, in a mouse model approximating human HCC with poor prognosis, leading to an investigator Phase 1B-2 clinical trial. Comparative st...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-37129 | biostudies-arrayexpress
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