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MetabolomicsDeletion of Gja1 in myocardium emerges ventricular arrhythmia and tachycardia by reprogramming proline metabolism
Connexin43 (Cx43) is the predominant connexin in working myocardium. Its expression decreases in various cardiovascular diseases, and accompanied by ventricular arrhythmias (VAs). However, molecular mechanisms underlying increased arrhythmogenesis remained unclear. Here we established iPSC-derived c...
2025-11-11 | MTBLS13302 | MetaboLights
ProteomicsResveratrol Suppresses Susceptibility of Ventricular Arrhythmia in Heart Failure Model
In a rabbit heart failure model, resveratrol treatment restored cardiac function, normalized calcium handling, and reduced ventricular arrhythmia by reversing ion channel downregulation, fibrosis, apoptosis, and inflammation. These findings highlight resveratrol’s cardioprotective potential as a the...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2026-01-12 | PXD069110 | Pride
Heart failure Calcium handling Ion channels Ventricular arrhythmia Optical mapping 
GenomicsCardiac Arrhythmia Suppression Trial (CAST-BioLINCC)
Cardiac Arrhythmia Suppression Trial (CAST-BioLINCC)
PRJNA1454961 | ENA
GenomicsCardiac Arrhythmia Suppression Trial (CAST-BioLINCC)
Cardiac Arrhythmia Suppression Trial (CAST-BioLINCC)
PRJNA1454962 | ENA
UnknownReal-Time Closed-Loop Suppression of Repolarization Alternans Reduces Arrhythmia Susceptibility In Vivo.
Not available
S-EPMC7334752 | biostudies-literature
ProteomicsProteomics Study and Protein Biomarkers of Malignant Ventricular Arrhythmia in Acute Myocardial Infarction Patients
Acute myocardial infarction (AMI) is one of the leading causes of death. It is particularly important to predict malignant ventricular arrhythmia (MVA) timely and accurately in patients with AMI. This study aimed to explore biomarkers and to reveal possible mechanisms of MVA in AMI for clinical diag...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041535 | Pride
Acute myocardial infarction  malignant ventricular arrhythmia  proteomics  data independent acquisition 
UnknownGlobal disparities in arrhythmia care: Mind the gap.
Not available
S-EPMC9795303 | biostudies-literature
UnknownhiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen.
Not available
S-EPMC5653750 | biostudies-literature
GenomicsNHLBI TOPMed: The Cleveland Clinic Atrial Fibrillation Study of the CV/Arrhythmia Biobank
NHLBI TOPMed: The Cleveland Clinic Atrial Fibrillation Study of the CV/Arrhythmia Biobank
PRJNA338828 | ENA
UnknownThe role of iPSC research for insight into inherited arrhythmia conditions.
Not available
S-EPMC12554002 | biostudies-literature
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