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Kinase-substrate networks are the main components of many signal transduction pathways. Although proteome-wide studies have been successful in elucidating many important biological events including the cataloging of thousands of sites of protein phosphorylation, there is a lack of a universal method...
ORGANISM(S): Homo sapiens (Human) 
2017-11-08 | PXD004739 | Pride
The protein content of amnion is thought to be the primary contributor to its efficacy as a biological dressing for wounds. Protein elution into antibiotic processing media has been reported, but the effect of antiseptic-based processing methods is unknown. Here, proteomic analyses of equine amnion ...
ORGANISM(S): Cellular Organisms 
The protozoan parasite Cryptosporidium is a leading cause of diarrhea associated mortality in young children. The parasite’s lifecycle involves a highly coordinated and timely progression from asexual proliferative to sexual stages leading to formation of the transmissible oocyst. Underlying molecul...
ORGANISM(S): Cellular Organisms 
The kinase assay linked phosphoproteomics (KALIP) strategy was used to identify direct substrates of the Abelson tyrosine kinase (ABL). First, kinase assays using peptides and proteins from chronic myelogenous leukemia cells and recombinant ABL were done to identify kinase substrates in vitro. The A...
ORGANISM(S): Homo Sapiens (human) 
Feather follicle epithelium samples were collected from chickens that were infected with Marek's disease virus (MDV). The proteome and phosphoproteome of MDV were then interrogated by high resolution LC-MS.
ORGANISM(S): Gallid Alphaherpesvirus 2 
Platelet lysate (PL) demonstrates antimicrobial and anti-inflammatory properties and may offer potential for treatment of bacterial pneumonia in horses. It remains unknown whether nebulization represents a suitable method of administration of PL in horses. This study characterized particle size and ...
ORGANISM(S): Equus Caballus 
The increasing global prevalence of diabetic nephropathy poses substantial health and economic burdens. Currently, effective anti-fibrotic therapies for managing kidney fibrosis associated with chronic kidney disease are lacking. This study reveals corisin, a microbiota-derived peptide, as a central...
ORGANISM(S): Cellular Organisms 
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