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ProteomicsIdentification of Direct Upstream Kinases by Fluorescence Complementation Mass Spectrometry
Kinase-substrate networks are the main components of many signal transduction pathways. Although proteome-wide studies have been successful in elucidating many important biological events including the cataloging of thousands of sites of protein phosphorylation, there is a lack of a universal method...
ORGANISM(S): Homo sapiens (Human) 
2017-11-08 | PXD004739 | Pride
Fcms Kinases Fluorescence complementation Phosphorylation 
ProteomicsThe Cryptosporidium signaling kinase CDPK5 plays an important role in male gametogenesis and parasite virulence
The protozoan parasite Cryptosporidium is a leading cause of diarrhea associated mortality in young children. The parasite’s lifecycle involves a highly coordinated and timely progression from asexual proliferative to sexual stages leading to formation of the transmissible oocyst. Underlying molecul...
ORGANISM(S): Cellular Organisms 
2024-06-04 | PXD051082 | JPOST Repository
ProteomicsCharacterization of Equine Platelet Lysate for Nebulization in the Horse
Platelet lysate (PL) demonstrates antimicrobial and anti-inflammatory properties and may offer potential for treatment of bacterial pneumonia in horses. It remains unknown whether nebulization represents a suitable method of administration of PL in horses. This study characterized particle size and ...
ORGANISM(S): Equus Caballus 
2024-12-26 | PXD055023 | JPOST Repository
ProteomicsMicrobiota-Derived Corisin Accelerates Kidney Fibrosis by Promoting Cellular Aging
The increasing global prevalence of diabetic nephropathy poses substantial health and economic burdens. Currently, effective anti-fibrotic therapies for managing kidney fibrosis associated with chronic kidney disease are lacking. This study reveals corisin, a microbiota-derived peptide, as a central...
ORGANISM(S): Cellular Organisms 
2026-01-30 | PXD060522 | JPOST Repository
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