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ProteomicsQuantitative proteomics of mitochondria isolated from rat pulmonary arterial smooth muscle cells under normoxia and chronic hypoxia
Primary pulmonary arterial smooth muscle cells (PASMCs) were isolated from rat lungs by an arterial tracing method and cultured to passage 4. Cells were exposed to normoxia (21% O2) or hypoxia (1% O2) for 48 h. A mitochondria-enriched fraction was prepared from each culture and analysed by label-fre...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-14 | PXD083383 | Pride
Rat Hypoxia Mitochondria Cytochrome c oxidase Data-independent acquisition Pasmc Pulmonary arterial smooth muscle cell Cox4i2 
ProteomicsIntegrative Proteomic and Bioenergetic Profiling Reveals Diet- and Strain-Specific Mitochondrial Dysfunction in Cohen Diabetic Rat Hearts
Cytochrome-c oxidase (CcO) is the terminal enzyme of the electron transport chain, where it catalyzes the reduction of oxygen to water. The oxygen-binding site is located near subunit I (CcO1), which is subject to tight regulatory control, including phosphorylation. Under diabetic conditions associa...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-08-17 | PXD066170 | Pride
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