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TranscriptomicsTranscription profiling of human normal subjects and IPAH patients to examine the effect of BMP-2 on pulmonary artery smooth muscle cells
Bone morphogenetic proteins (BMP) inhibit proliferation and induce apoptosis in pulmonary artery smooth muscle cells (PASMC) from normal subjects. Dysfunction of BMP signaling due to mutations in and/or downregulation of BMP receptors has been implicated in idiopathic pulmonary arterial hypertension...
ORGANISM(S): Homo sapiens 
2007-09-07 | E-GEOD-2559 | biostudies-arrayexpress
GenomicsRevealing the target of PASMC from PAH patients and mechanism
Revealing the target of PASMC from PAH patients and mechanism
PRJNA714539 | ENA
TranscriptomicsRNA-SEQ assay for wild type and CRISPR induced endoglin knockout human pulmonary artery smooth muscle cells (PASMC)
The goal of this study is to investigate the differential transcripted genes affected by CRISPR induced endoglin knockout in PASMC cells. Total RNA was purified from NTC or ENG-/- PASMC cells using RNeasy Mini Kit (Qiagen, Hilden, Germany). RNA quality and concentration were assessed with Agilent Ta...
ORGANISM(S): Homo sapiens 
2017-05-16 | E-GEOD-78271 | biostudies-arrayexpress
ProteomicsDARTS-MS chemoproteomic profiling of ginkgolide J-associated protease-susceptibility candidate proteins in rat PASMC lysates
This dataset contains DIA-MS raw files and processed DIA-NN results from a DARTS-MS chemoproteomic experiment designed to identify ginkgolide J-associated protease-susceptibility candidate proteins in primary rat pulmonary artery smooth muscle cell (PASMC) lysates. The experiment included three grou...
ORGANISM(S): Rattus Norvegicus 
2026-05-25 | PXD078800 |
TranscriptomicsRevealing the target of PASMC from PAH patients and mechanism
The goal of this study is to identify the target of PAH in PASMC from donor control and PAH patients by transcriptome profiling (RNA-seq) and the mechanism from transcriptome profiling (RNA-seq) and histone modification (ChIPseq)
ORGANISM(S): Homo sapiens 
2021-07-28 | GSE168905 | GEO
TranscriptomicsRNA-SEQ assay for wild type and CRISPR induced endoglin knockout human pulmonary artery smooth muscle cells (PASMC)
The goal of this study is to investigate the differential transcripted genes affected by CRISPR induced endoglin knockout in PASMC cells.
ORGANISM(S): Homo sapiens 
2017-05-16 | GSE78271 | GEO
TranscriptomicsEndothelin-1 driven proliferation of PASMC is c-fos dependent
Background: Pulmonary hypertension is a rare disease characterized by pulmonary artery smooth muscle cell (PASMC) proliferation leading to vascularremodeling. Multiple factors have been associated with the vessel wall thickening. However, the responsible mechanisms are not fully understood. Aim: In ...
ORGANISM(S): Mus musculus 
2014-04-11 | GSE56698 | GEO
UnknownSTIM2 (Stromal Interaction Molecule 2)-Mediated Increase in Resting Cytosolic Free Ca2+ Concentration Stimulates PASMC Proliferation in Pulmonary Arterial Hypertension.
Not available
S-EPMC5955710 | biostudies-literature
TranscriptomicsEndothelin-1 driven proliferation of PASMC is c-fos dependent
Background: Pulmonary hypertension is a rare disease characterized by pulmonary artery smooth muscle cell (PASMC) proliferation leading to vascularremodeling. Multiple factors have been associated with the vessel wall thickening. However, the responsible mechanisms are not fully understood. Aim: In ...
ORGANISM(S): Mus musculus 
2014-04-11 | E-GEOD-56698 | biostudies-arrayexpress
TranscriptomicsA critical role of microRNAs in human pulmonary arterial hypertension. miR-204: a novel therapeutic target (TaqMan qPCR)
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease characterized by enhanced pulmonary artery smooth muscle cell (PASMC) proliferation and suppressed apoptosis. Downregulation of the BMPR2 gene along with activation of the transcription factor NFAT have been implicated in the mai...
ORGANISM(S): Homo sapiens 
2010-12-16 | E-GEOD-21281 | biostudies-arrayexpress
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