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TranscriptomicsDeep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of arsenite
Background: Arsenite is one of the most toxic chemical substances known and is assumed to exert detrimental effects on viability even at lowest concentrations. By contrast and unlike higher concentrations, we here find that exposure to low-dose arsenite promotes growth of cultured mammalian cells. I...
ORGANISM(S): Caenorhabditis elegans 
2013-04-23 | E-GEOD-46257 | biostudies-arrayexpress
TranscriptomicsRemodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates (part 1)
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Ago2/microRNA machinery has been shown to participate in stre...
ORGANISM(S): Homo sapiens 
2013-07-15 | E-GEOD-44376 | biostudies-arrayexpress
TranscriptomicsRemodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates (part 4)
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Ago2/microRNA machinery has been shown to participate in stre...
ORGANISM(S): Homo sapiens 
2013-07-15 | E-GEOD-44379 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of root tissue from rice grown on arsenite-spiked sediments
The experiment intended to identify biomarker genes for arsenite exposure in rice roots. These biomarker genes were tested as alternative endpoints in an sediment-contact test with rice (Brinke et al. Environ Sci Pollut R 22.16 (2015): 12664-12675)
ORGANISM(S): Oryza sativa Indica Group 
2017-10-01 | E-MTAB-5430 | biostudies-arrayexpress
TranscriptomicsRibosome profiling data obtained from HEK293T cells 30 minutes after treatment with arsenite to a final concentration of 40 M-BM-5M
Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions. This can be achieved by the phosphorylation-mediated inactivation of a key translation initiation factor, eIF2. However, the persistent translation of certain mRNAs is required for deployment of an adequate s...
ORGANISM(S): Homo sapiens 
2015-01-27 | E-GEOD-55195 | biostudies-arrayexpress
TranscriptomicsRemodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates (part 3)
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Ago2/microRNA machinery has been shown to participate in stre...
ORGANISM(S): Homo sapiens 
2013-07-15 | E-GEOD-44378 | biostudies-arrayexpress
MetabolomicsSelective profiling of translationally active tRNAs and their dynamics under stress

During translation, transfer RNAs (tRNAs) deliver specific amino acids to the ribosome in a coordinated manner with the sequence encoded by the mRNA. Despite their central role in protein synthesis, the precise contribution of tRNAs to the modulation of translation remains poorly understood, prim...

2026-06-25 | MTBLS12806 | MetaboLights
ProteomicsSILAC-based Quantitative Proteomic Analysis Unveiled the Arsenite-induced Perturbation of Multiple Pathways in Human Skin Fibroblast Cells
Humans are exposed to arsenic species through inhalation, ingestion and dermal contact, which may lead to skin, liver, and bladder cancers as well as cardiovascular and neurological diseases. The mechanisms underlying the cytotoxic and carcinogenic effects of arsenic species, however, remain incompl...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005646 | Pride
Mass spectrometry Arsenite Silac Oxidative stress Quantitative proteomics 
TranscriptomicsRemodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates (part 2)
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Ago2/microRNA machinery has been shown to participate in stre...
ORGANISM(S): Homo sapiens 
2013-07-15 | E-GEOD-44377 | biostudies-arrayexpress
ProteomicsPEPseq Quantifies Transcriptome-Wide Changes in Protein Occupancy and Reveals Selective Translational Repression After Translational Stress
Post-transcriptional gene regulation is accomplished by the interplay of the transcriptome with RNA-binding proteins, which occurs in a dynamic manner in response to altered cellular conditions. Recording the combined occupancy of all proteins binding to the transcriptome offers the opportunity to i...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042395 | Pride
Nascent proteome enrichment Protein-rna crosslinking Aha Protein occupancy on rna Arsenite washout Recovery from translational arrest Silac 
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