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Proteomics,MultiomicsSystematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits.
Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, DeGrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, Andersen MS, Root DE, von Andrian U, Jones RB, Park H; Carr SA, Regev A, Amit I, Hacohen N. Cell, 2011, 147(4) 853-867. doi: 10...
2013-12-10 | MSV000078507 | MassIVE
TranscriptomicsTargeted chromatin profiling reveals novel enhancers in Ig heavy and light chain loci.
Chip-chip from pro-B cells from Rag1KO mice for H3K27ac and RNA Pol II Identification of novel enhancers from Ig heavy and light chain loci Rag1KO pro-B epigenetic landscape at Ig heavy and light chain loci
ORGANISM(S): Mus musculus 
2014-01-03 | E-GEOD-53766 | biostudies-arrayexpress
ProteomicsEnhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome
The impact of healthy aging on molecular programming of immune cells is poorly understood. Here, we report comprehensive characterization of healthy aging in human classical monocytes, with a focus on epigenomic, transcriptomic, and proteomic alterations, as well as the corresponding proteomic and m...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD021821 | Pride
Human  monocyte  aging 
TranscriptomicsHigh-throughput integration of metabolic and transcriptional profiles reveals major metabolic regulators of macrophage polarization
Macrophages polarize to divergent functional phenotypes depending on their microenvironment in a highly coordinated process of metabolic and transcriptional rewiring that is still poorly understood. We developed an Integrated Metabolomics and Gene Expression (IMAGE) profiling and analysis pipeline a...
ORGANISM(S): Mus musculus 
2014-05-30 | E-GEOD-53053 | biostudies-arrayexpress
TranscriptomicsTissue-Resident Natural Killer (NK) Cells Are Cell Lineages Distinct From Thymic and Conventional Splenic NK Cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-04-26 | E-GEOD-52047 | biostudies-arrayexpress
TranscriptomicsTissue-Resident Natural Killer (NK) Cells Are Cell Lineages Distinct From Thymic and Conventional Splenic NK Cells (part 1)
Natural killer (NK) cells belong to the innate immune system where they can control virus infections and developing tumors by cytotoxicity and production of inflammatory cytokines. Most studies of mouse NK cells, however, have focused on conventional NK (cNK) cells found in the spleen. Recently, we ...
ORGANISM(S): Mus musculus 
2014-04-26 | E-GEOD-52043 | biostudies-arrayexpress
TranscriptomicsTissue-Resident Natural Killer (NK) Cells Are Cell Lineages Distinct From Thymic and Conventional Splenic NK Cells (part 2)
Natural killer (NK) cells belong to the innate immune system where they can control virus infections and developing tumors by cytotoxicity and production of inflammatory cytokines. Most studies of mouse NK cells, however, have focused on conventional NK (cNK) cells found in the spleen. Recently, we ...
ORGANISM(S): Mus musculus 
2014-04-26 | E-GEOD-52045 | biostudies-arrayexpress
TranscriptomicsA Unifying Model for Molecular Determinants of the Pre-selection Vβ Repertoire [ChIP-chip]
Chip-chip from pro-T(DN) cells from Rag1KO mice for H3K27ac, P300 and FAIRE The primary antigen receptor repertoire is sculpted by the process of V(D)J recombination, which must strike a balance between diversification and favoring gene segments with specialized functions. The precise determinants o...
ORGANISM(S): Mus musculus 
2013-08-14 | E-GEOD-42851 | biostudies-arrayexpress
TranscriptomicsType 1 interferons induce changes in core metabolism that are critical for immune function
Type 1 interferons (IFNs) induce complex responses that can be beneficial or deleterious, depending on context. Greater understanding of the mechanisms of action of these cytokines could allow new therapeutic approaches. We found that type 1 IFNs induced changes in cellular metabolism that were cr...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81889 | biostudies-arrayexpress
ProteomicsUsing FAIMS to improve tumor neoantigen detection
DDA and PRM analysis, with and without FAIMS, for the T3, F244, and 1956 MCA sarcoma cell lines. PRM analysis of MHC-I neoantigens in ex vivo mouse tumors.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-08-08 | MSV000092617 | MassIVE
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