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TranscriptomicsIntegrative genomic analysis identifies clinically relevant subtypes of head and neck cancer characterized by hypoxia, T-cell infiltration, and EMT
Current classification of head and neck squamous cell carcinomas (HNSCC) based on anatomic site and clinical stage fails to capture biologic heterogeneity or adequately inform treatment. Here we use consensus clustering on 371 HNSCC in three cohorts, including a new cohort of 134 patients with locor...
ORGANISM(S): Homo sapiens 
2015-03-04 | E-GEOD-40774 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of human fetal hearts at 9, 12 and 16 weeks of gestation
RNA-Seq was used to study alterations in gene expression in the developing human heart across three gestational ages in the first and early second trimester. All tissue was acquired following elective termination of pregnancy and informed parental consent. Storage and use of tissue was in premises l...
ORGANISM(S): Homo sapiens 
2018-10-24 | E-MTAB-7031 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Plasmodium berghei PbWT and PbHMGB1KO parasite strains
The purpose of the experiment is to identify the differential gene expression pattern of PbHMGB1KO parasites with respect to the PbWT parasites.
ORGANISM(S): Plasmodium berghei 
2024-09-17 | E-MTAB-14378 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of atmbd4, atmbd6 and atmbd11 mutants of Arabidopsis thaliana
Methyl CpG Binding (MBD) proteins are a class of protein that binds with methylated DNA. In the model plant Arabidopsis thaliana there are 13 MBD proteins are there. To understand the gene regulation we performed microarray analysis of mutants of three genes (atmbd4, atmbd6 and atmbd11). Ten day old...
ORGANISM(S): Arabidopsis thaliana 
2014-07-09 | E-GEOD-59133 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Bos taurus 4 brain areas at either of 2 phases of oestrous cycle
The experiment is part of a study aimed at identifying and studying genes that contribute to differences in oestrous behaviour expression and fertility levels of dairy cows. Samples from 4 brain areas (dorsal hypothalamus, ventral hypothalamus, amygdala and hippocampus) and the anterior pituitary we...
ORGANISM(S): Bos taurus 
2011-02-03 | E-TABM-916 | biostudies-arrayexpress
TranscriptomicsSystems Toxicology Identifies Mechanistic Impacts of 2-amino-4,6-dinitrotoluene (2-ADNT) Exposure in Northern Bobwhite
A systems toxicology investigation comparing and integrating transcriptomic and proteomic results was conducted to pursue a holistic understanding of the effects of the explosives degradation product 2-amino-4,6-dinitrotoluene (2A-DNT) dosing on the health of the wildlife bird model, Northern bobwhi...
ORGANISM(S): Colinus virginianus 
2015-07-01 | E-GEOD-59910 | biostudies-arrayexpress
TranscriptomicsIdentification and characterization of miRNAome in root, stem, leaf and tuber developmental stages of potato (Solanum tuberosum L.) by high-throughput sequencing
Purpose: MicroRNAs (miRNAs) are ubiquitous components of endogenous plant transcriptome. miRNAs are small, single-stranded and ~21 nt long RNAs which regulate gene expression at the post-transcriptional level and are known to play essential roles in various aspects of plant development and growth. P...
ORGANISM(S): Solanum tuberosum 
2014-01-09 | E-GEOD-52599 | biostudies-arrayexpress
TranscriptomicsRNA_seq_Salmonella_pig
Salmonella enterica serovar Typhimurium is a gram-negative bacterium that can colonize the gut of humans and several species of food producing farm animals to cause enteric or septicaemic salmonellosis. Besides compromising public health and food safety, sub-clinical salmonellosis is also believed t...
ORGANISM(S): Sus scrofa 
2014-06-11 | E-MTAB-2234 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of livers from mice fed high-fat diet and high fructose-glucose solution for 8 weeks
The lack of a preclinical model of nonalcoholic steatohepatitis (NASH) and hepatocellular cancer (HCC) that recapitulates human disease is a major barrier to therapeutic development. We report a high fat-high sugar diet-induced NASH and HCC in a stable isogenic 129S1/SvImJ crossed with C57Bl/6J mice...
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-67678 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of livers and liver tumors from mice fed high-fat diet and high fructose-glucose solution for 52 weeks
The lack of a preclinical model of nonalcoholic steatohepatitis (NASH) and hepatocellular cancer (HCC) that recapitulates human disease is a major barrier to therapeutic development. We report a high fat-high sugar diet-induced NASH and HCC in a stable isogenic 129S1/SvImJ crossed with C57Bl/6J mice...
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-67679 | biostudies-arrayexpress
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